摘要
目的分析咽喉反流(LPR)与咽喉常见疾病的关系及其发生的危险因素。方法选取2022年9月~2023年5月因咽喉不适就诊于哈尔滨医科大学附属第一医院耳鼻咽喉头颈外科住院部或喉镜室的280例患者作为研究对象,入组患者均需完成反流症状指数(RSI)和反流体征评分(RFS)量表。根据RSI>13分和(或)RFS>7分为LPR组,RSI≤13分且RFS≤7分为非LPR组。采用χ^(2)检验分析不同组间咽喉常见疾病上呼吸道乳头状瘤、会厌囊肿、声带息肉、声带白斑、声带癌、下咽癌发生率的差异,对性别、年龄、体重指数(BMI)、吸烟、饮酒史进行单因素卡方检验分析和多因素二元Logistic回归分析。结果280例因咽喉不适就诊的患者中,LPR患病率为70.0%(196/280)。声带息肉(χ^(2)=4.228,P<0.05)、声带白斑(χ^(2)=12.283,P<0.05)、声带癌(χ^(2)=4.103,P<0.05)和下咽癌(χ^(2)=4.907,P<0.05)在LPR组和非LPR组中发生率的比较差异有统计学意义,而上呼吸道乳头状瘤(χ^(2)=0.183,P>0.05)和会厌囊肿(χ^(2)=0.556,P>0.05)差异比较无统计学意义。单因素分析结果显示,吸烟(χ^(2)=20.403,P<0.05)、饮酒(χ^(2)=7.704,P<0.05)在LPR组和非LPR组中发生率的比较差异有统计学意义,而性别(χ^(2)=0.01,P>0.05)、年龄(χ^(2)=8.147,P>0.05)、BMI(χ^(2)=2.060,P>0.05)差异无统计学意义。多因素二元Logistic回归分析结果显示,吸烟(OR=3.390,95%CI:1.761~6.526,P<0.05)是LPR发生的独立危险因素。结论LPR与声带息肉、声带白斑、声带癌及下咽癌有较高的共患病率,因此在治疗咽喉相关疾病时应评估LPR情况,必要时也应该积极治疗LPR。此外吸烟、饮酒是LPR发生的危险因素,因此在治疗LPR时戒烟戒酒很有必要。
OBJECTIVE To analyze the relationship between LPR and common pharyngeal diseases and its risk factors.METHODS A total of 280 patients who were admitted to the Inpatient Department of Otolaryngology Head and Neck Surgery or Laryngoscopy Room of the First Affiliated Hospital of Harbin Medical University due to throat discomfort from September 2022 to May 2023 were selected as the study objects.All enrolled patients were required to complete the RSI and RFS scoring scales.According to the 2022 LPRD expert Consensus,RSI>13 and/or RFS>7 were classified as LPR group,and RSI≤13 and RFS≤7 are classified as non-LPR group.Chi-square test was used to analyze the differences in the incidence of common pharyngeal diseases such as upper respiratory tract papilloma,epiglottic cyst,vocal cord polyp,vocal cord leucoplakia,vocal cord cancer and hypopharyngeal cancer among different groups.Univariate Chi-square test analysis and multivariate binary logistic regression analysis were performed for gender,age,BMI,smoking and drinking history.All differences were statistically significant with P<0.05.RESULTS The prevalence of LPR in 280 patients with throat discomfort was 70.0%(196/280).There were statistically significant differences in the incidence of LPR group and non-LPR group in patients with vocal cord polyp(χ^(2)=4.228,P<0.05),vocal cord leukoplakia(χ^(2)=12.283,P<0.05),vocal cord cancer(χ^(2)=4.103,P<0.05)and hypopharyngeal cancer(χ^(2)=4.907,P<0.05),while there was no significant difference in the incidence of LPR group and non-LPR group in patients with papilloma of upper respiratory tract(χ^(2)=0.183,P>0.05)and epiglottic cyst(χ^(2)=0.556,P>0.05).Univariate analysis showed that there were significant differences in the incidence rates of smoking(χ^(2)=20.403,P<0.05)and drinking(χ^(2)=7.704,P<0.05)between the LPR group and the non-LPR group,while gender(χ^(2)=0.01,P>0.05),age(χ^(2)=8.147,P>0.05),BMI(χ^(2)=2.060,P>0.05)had no significant difference.Multivariate logistic regression analysis showed that smoking(O
作者
郑念东
刘江涛
姜琳琳
高茜
ZHENG Niandong;LIU Jiangtao;JIANG Linlin;GAO Qian(Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150000,China)
出处
《中国耳鼻咽喉头颈外科》
CSCD
2024年第1期45-48,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
基金
哈医大一院科研创新基金(2021M12)。
关键词
危险因素
诊断
咽喉反流
患病率
咽喉相关疾病
Risk Factors
Diagnosis
laryngopharyngeal reflux
prevalence rate
throat related diseases
