摘要
目的探讨脑梗死患者HbAlc、RDW-CV、RDW-SD和RPR水平,并分析以上指标与病情及预后关系。方法选取2021年1月至2022年10月我院收治的104例脑梗死患者为病例组,另选同期在我院进行健康体检的100名健康者为对照组。病例组按病情严重程分为轻度组43例、中度组35例和重度组26例。比较各组间的HbAlc、RDW-CV、RDW-SD、RPR水平,通过Spearman法分析HbAlc、RDW-CV、RDW-SD、RPR与疾病严重程度的相关性。对病例组患者出院后进行3个月随访,按患者的预后情况分为预后良好组72例、预后不良组32例,收集临床资料,并分析各指标预测脑梗死患者预后不良的价值。结果脑梗死患者轻、中、重度各组的HbAlc、RDW-CV、RDW-SD、RPR水平均高于对照组,且各指标水平随疾病严重程度递增而升高(P<0.05);Spearman相关性分析结果显示,HbAlc、RDW-CV、RDW-SD、RPR与疾病严重程度呈正相关(P<0.05);预后不良组HbAlc、RDW-CV、RDW-SD、RPR水平高于预后良好组(P<0.05);ROC曲线分析显示,HbAlc、RDW-CV、RDW-SD、RPR及联合检测的曲线下面积(AUC)为0.752、0.732、0.715、0.705、0.824,其中联合检测的预测价值最佳。结论HbAlc、RDW-CV、RDW-SD、RPR在一定程度上可反映脑梗死严重程度,且对预后具有一定预测价值,可作为疾病严重程度以及预后不良的预测因子。
Objectives To investigate the levels of glycosylated hemoglobin(HbAlc),red blood cell distribution width coefficient of variation(RDW-CV),red blood cell distribution width standard deviation(RDW-SD)and red blood cell distribution width toplatelet count ratio(RPR)in patients with cerebral infarction,and to analyze the relationship between the above indicators and the condition and prognosis.Methods A total of 104 patients with cerebral infarction admitted to Guangzhou Dongsheng Hospital from January 2021 to October 2022 were selected as the case group,and another 100 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.The case group were divided into mild group(n=43),moderate group(n=35),and severe group(n=26)according to the disease severity.The levels of HbAlc,RDW-CV,RDW-SD,and RPR in each group were compared.The correlation between HbAlc,RDW-CV,RDW-SD,RPR and disease severity was analyzed through Spearman method.The patients in the case group were followed up for 3 months after discharge.According to the prognosis condition,the patients were divided into the group with good prognosis(n=72)and the group with poor prognosis(n=32).The clinical data were collected,and the value of each index in predicting the poor prognosis of patients with cerebral infarction was analyzed.Results The levels of HbAlc,RDW-CV,RDW-SD and RPR in the mild,moderate and severe groups of cerebral infarction patients were higher than those in the control group,and the levels of each index increased with the increasing severity of the disease(P<0.05).Spearman correlation analysis showed that HbAlc,RDW-CV,RDW-SD and RPR were positively correlated with disease severity(P<0.05).The levels of HbAlc,RDW-CV,RDW-SD,and RPR were higher in the poor prognosis group than those in the good prognosis group(P<0.05).ROC curve analysis revealed that the area under curve(AUC)of HbAlc,RDW-CV,RDW-SD,RPR and the combined detection were 0.752、0.732、0.715、0.705、0.824,respectively,and
作者
詹佳
赖聪玲
陈文丽
ZHAN Jia;LAI Congling;CHEN Wenli(Guangzhou Dongsheng Hospital,Guangzhou 510760,Guangdong,China)
出处
《现代诊断与治疗》
CAS
2023年第22期3327-3329,3332,共4页
Modern Diagnosis and Treatment
关键词
脑梗死
糖化血红蛋白
红细胞分布宽度
血小板计数比值
Cerebral infarction
Glycosylated hemoglobin
Red cell distribution width
Platelet count ratio
