摘要
目的探究超声内镜、巨噬细胞抑制因子-1(MIC-1)、血清肿瘤标志物糖类抗原19-9(CA19-9)联合诊断胰腺癌的临床价值。方法选取2019年3月至2022年3月在南京医科大学附属苏州市立医院行超声内镜检查的100例高度疑似胰腺癌患者作为观察组,同期来院进行体检的50例健康志愿者作为对照组。采用化学发光法检测CA19-9水平,采用酶联免疫法检测MIC-1水平并进行组间比较。以术后患者的病理检查结果为金标准,比较超声内镜、MIC-1、CA19-9分别及联合应用对胰腺癌的诊断价值。结果2组研究对象的血清CA19-9、MIC-1水平比较差异有统计学意义(P<0.05)。与健康对照组相比较,观察组患者的血清CA19-9、MIC-1水平更高,差异有统计学意义(P<0.05)。超声内镜、MIC-1、CA19-9三者联合诊断的敏感度(84.21%)均低于三者分别诊断(92.11%、90.79%、90.79%),特异度(91.67%)均高于三者分别诊断(79.17%、83.33%、75.00%)。三者联合诊断的阳性预测值为96.97%,阴性预测值为64.71%。结论在对胰腺肿瘤进行良恶性诊断时,采用超声内镜、MIC-1、CA19-9联合诊断可以有效提高其诊断效能。
Objective To explore the diagnostic value of endoscopic ultrasound combined with macrophage inhibitory factor⁃1(MIC⁃1)and serum tumor⁃marker carbohydrate antigen 19⁃9(CA19⁃9)in pancreatic cancer.Methods One hundred patients with highly suspected pancreatic cancer(observation group)who underwent endoscopic ultrasonography at Suzhou Municipal Hospital between March 2019 and March 2022 and 50 healthy volunteers(control group)were enrolled in this study.Their CA19⁃9 levels were detected by chemiluminescence and MIC⁃1 levels were measured by enzyme⁃linked immunoassay.Pathological results of patients after surgery were taken as the golden standard.The diagnostic value of endoscopic ultrasound,MIC⁃1 or CA19⁃9 and their combined evaluation in pancreatic cancer was analyzed.Results Serum CA19⁃9 and MIC⁃1 levels in the observation group were significantly higher than those in the control group(P<0.05).The sensitivities of endoscopic ultrasound,MIC⁃1,and CA19⁃9 in diagnosis of pancreatic cancer was 92.11%,90.79%,and 90.79%,respectively,which were higher than their combined evaluation(84.21%).The specificity of endoscopic ultrasound,MIC⁃1,and CA19⁃9 in diagnosis of pancreatic cancer were 79.17%,83.33%,and 75.00%,respectively,which were lower than their combined evaluation(91.67%).The positive predictive value of combined evaluation was 96.97%,and the negative predictive value was 64.71%.Conclusion In the diagnosis of pancreatic cancer,combined use of endoscopic ultrasound,MIC⁃1 and CA19⁃9 can effectively improve the diagnostic efficiency.
作者
郑舒丹
杨柳
Zheng Shudan;Yang Liu(Department of Gastroenterology,Suzhou Municipal Hospital,Nanjing Medical University,Suzhou 215000,China)
出处
《海军医学杂志》
2024年第2期151-155,共5页
Journal of Navy Medicine
