摘要
目的探讨血清巨噬细胞抑制因子I（MIC-1）、骨桥蛋白（OPN）及糖类抗原19—9（CA19—9）联合检测在诊断胰腺癌患者中的应用价值。方法纳入60例健康者为对照组与63例胰腺癌患者为观察组进行研究，均收集血清进行MIC-1、OPN及CA19—9水平检测。结果对两组的血清MIC-1、OPN、CA19—9水平进行检测和比较，对照组的上述指标水平分别为（485．12±75．23）pg／ml、（35．12±15．12）ng／ml、（26．34±2．47）U/ml，均显著低于观察组的（1559．15±225．16）pg／ml、（115．25±35．23）ng／ml、（195．12±18．25）U／ml，（t=15．21、8．15、9．12，P〈0．05）。3种指标单独检测，以MIC-1检测的敏感性最高，显著高于其他2项指标（x^2=5．12、6．03，P〈0．05），其他2项指标差异无统计学意义（P〉0．05）。CA19—9检测的特异性最高，显著高于其他2项指标（x^2=5．88、5．75，P〈0．05），其他2项指标差异无统计学意义（P〉0．05）。3种检测方法的准确性基本相当，差异均无统计学意义（均P〉0．05），MIC-1＋OPN＋CA19—9检测的敏感性和特异性以及准确性均显著高于3项指标单独检测的水平，差异均有统计学意义（均P〈0．05）。结论胰腺癌诊断中实施MIC-1、OPN及CA19—9联合检测可以获得更好的检测结果，显著提高检测的准确性等，具有-定的临床应用价值。
Objective To explore the application value of serum macrophage inhibitory factor 1 （MIC-1）, osteopontin （OPN）, and carbohydrate antigen 19-9 （CA19-9） combined detection in the diagnosis of pancreatic cancer patients. Method 60 healthy persons and 63 cases of pancreatic cancer were collected for serum MIC-1, OPN, and CA19-9 levels detection in the study. Results Serum MIC-1, OPN, and CA19-9 levels in the control group were respectively （485.12±75.23）pg/ml, （35.12± 15.12）ng/ml, （26.34±2.47）U/ml, significantly lower than those in the observation group [（1 559.15±225.16）pg/ml, （115.25±35.23）ng/ml, （ 195.12± 18.25）U/ml] （t= 15.21, 8.15, 9.12; P〈0.05）. MIC-1 single detection showed the highest sensitivity, significantly higher than that of the other two indexes （x^2=5.12, 6.03; P〈0.05）, without statistically significant difference between the other two indexes （P〉0.05）. CA19-9 single detection showed the highest specificity, significantly higher than that of the other two indexes （x^2=5.88, 5.75; P〈0.05）, without statistically significant difference between the other two indexes （P〉0.05）. The accuracy of the three methods were quite similar （P〉0.05）. The sensitivity, specificity, accuracy of MIC-1, OPN, and CA 19-9 combined detection were significantly higher than those of single detection of the three indexes （P〈0.05）. Conclusion MIC-1, OPN, and CA19-9 combined detection can obtain better results in the diagnosis of pancreatic cancer, significantly improve the accuracy of detection, with certain clinical application value.
出处
《国际医药卫生导报》
2017年第12期1934-1936,共3页
International Medicine and Health Guidance News
