摘要
近年来,相继有30种食药两用抗肿瘤中药被报道,这些中药分布非常广泛,主要分布在蔷薇科和豆科植物中,另外在鼠李科、伞形科、菊科等植物中也有分布。食药两用中药的有效成分类型也极其广泛,主要包括萜类、黄酮类、多糖类、提取物类等多种化学成分。因此,对其分别进行梳理和归纳,发现其中萜类化合物主要以五环三萜类和四环三萜类居多,其次是单萜类、倍半萜类、环烯醚萜苷类。黄酮类化合物主要含有黄酮类、异黄酮类,其次是黄酮醇类、二氢黄酮类。此外,发现大量的多糖类和提取物类化学成分存在于食药两用中药中。这些化学成分具有不同的药效作用,应用于不同类型的肿瘤疾病,且抗肿瘤作用机制也不尽相同,越来越多的研究也发现,这些食药两用中药主要通过抑制肿瘤细胞增殖、诱导肿瘤细胞发生凋亡、增强免疫调节等多方面来发挥抗肿瘤作用。系统综述了食药两用抗肿瘤中药的有效成分及作用机制,为食药两用抗肿瘤中药新药的研究以及产品的开发提供一定的理论依据。
In recent years,30 kinds of anti-tumor traditional Chinese medicines have been reported one after another,which are widely distributed,mainly in Rosaceae and Leguminosae,and also inRhamnaceae,Umbelliferae,Compositae and other plants.There are also a wide range of effective components in traditional Chinese medicine,including terpenoids,flavonoids,polysaccharides,extracts and other chemical components.Therefore,it is found that pentacyclic triterpenoids and tetracyclic triterpenoids are the main terpenoids,followed by monoterpenoids,sesquiterpenes and iridoid glycosides.Flavonoids mainly contain flavonoids and isoflavones,followed by flavonols and dihydroflavonoids.In addition,it is found that a large number of polysaccharides and extracts exist in traditional Chinese medicine for both food and medicine.These chemical components have different pharmacological effects and are applied to different types of tumor diseases,and their anti-tumor mechanisms are also different.More and more studies have also found that these dual-purpose Chinese medicines for food and medicine mainly play an anti-tumor role by inhibiting tumor cell proliferation,inducing tumor cell apoptosis and enhancing immune regulation.In this paper,the effective components and mechanism of anti-tumor traditional Chinese medicine for both food and medicine are systematically reviewed,which provides a theoretical basis for the research and product development of new anti-tumor traditional Chinese medicine for both food and medicine.
作者
马帅帅
章莹
徐玲霞
简晖
王飞
MA Shuaishuai;ZHANG Ying;XU Lingxia;JIAN Hui;WANG Fei(Academician Workstation,Jiangxi University of Chinese Medicine,Nanchang 330004,Jiangxi,China)
出处
《中华中医药学刊》
CAS
北大核心
2024年第1期184-188,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家重点研发计划项目(2019YFC1604905)
江西中医药大学校级科技创新团队发展计划项目(CXTD-22004)。
关键词
食药两用中药
抗肿瘤
有效成分
作用机制
TCM with both edible and medicinal uses
anti-tumor
active ingredients
mechanism
