摘要
目的探讨重复经颅磁刺激(rTMS)联合碳酸锂对双相情感障碍(BD)躁狂症患者临床疗效及认知功能的影响。方法选取2020年4月至2021年12月宜春市第三人民医院收治的60例BD躁狂症患者作为研究对象,采用随机数字表法分为对照组与联合治疗组,每组30例。对照组采用口服药物碳酸锂治疗,联合治疗组在对照组基础上联合rTMS治疗,比较两组威斯康星卡片分类测验(WCST)评分、生命质量综合评定问卷(GQOLI-74)评分、临床疗效及治疗满意度。结果治疗前,两组完成部分、正确部分、错误部分评分比较差异无统计学意义;治疗后,两组完成部分、正确部分评分均高于治疗前,错误部分评分均低于治疗前,且联合治疗组完成部分、正确部分评分均高于对照组,错误部分评分低于对照组,差异有统计学意义(P<0.05)。治疗前,两组社会功能、生活功能、健康功能评分比较差异无统计学意义;治疗后,联合治疗组社会功能、生活功能、健康功能评分均高于对照组,差异有统计学意义(P<0.05)。联合治疗组治疗总有效率为96.67%,高于对照组的73.33%,差异有统计学意义(P<0.05)。联合治疗组治疗总满意度为100.00%,高于对照组的73.33%,差异有统计学意义(P<0.05)。结论rTMS联合碳酸锂治疗BD躁狂症临床效果显著,不仅可提高BD患者的认知功能、生命质量,且患者满意度较高。
Objective To investigate the effects of repeated transcranial magnetic stimulation(rTMS)combined with lithium carbonate on the clinical efficacy and cognitive function of patients with bipolar disorder(BD)mania.Methods 60 patients with BD mania admitted to the Third People's Hospital of Yichun City from April 2020 to December 2021 were selected as the research subjects,and they were divided into the control group and combined treatment group according to the random number table method,with 30 cases in each group.The control group was treated with oral lithium carbonate,and the combined treatment group was treated with rTMS on the basis of the control group,the Wisconsin card sorting test(WCST)scores,the generic quality of life inventory 74(GQOLI-74)scores,clinical efficacy and the treatment satisfaction were compared between the two groups.Results Before treatment,there were no significant difference in the scores of completed part,correct part and wrong part between the two groups;after treatment,the scores of the completed part,the correct part of the two groups were higher than those before treatment,the score of the wrong part were lower than that before treatment,and the scores of the completed part,the correct part in the combined treatment group were higher than those in the control group,the score of the wrong part in the combined treatment group was lower than that in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the scores of social function,life function and health function between the two groups;after treatment,the scores of social function,life function and health function in the combined treatment group were higher than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate in the combined treatment group was 96.67%,which was higher than 73.33%in the control group,the difference was statistically significant(P<0.05).The treatment satisfaction in the combine
作者
赵梦颖
周伟
李庆
ZHAO Mengying;ZHOUWei;LI Qing(Department of Psychiatry,the Third People's Hospital of Yichun City,Yichun,Jiangxi,336000,China)
出处
《当代医学》
2023年第35期70-73,共4页
Contemporary Medicine
关键词
双相情感障碍躁狂症
重复经颅磁刺激
碳酸锂
临床疗效
认知功能
Bipolar disorder mania
Repeated transcranial magnetic stimulation
Lithium carbonate
Clinical efficacy
Cognitive function
