摘要
目的探讨喹硫平联合碳酸锂治疗双相情感障碍(BD)躁狂发作的临床效果.方法选取2020年1—12月我院收治的80例BD躁狂发作患者,按随机数字表法分为两组.对照组(n=40)口服碳酸锂治疗,观察组(n=40)在对照组基础上加用喹硫平治疗,持续用药4周.比较两组临床疗效、临床症状及不良反应发生情况.结果观察组治疗总有效率为92.50%,高于对照组的75.00%,差异有统计学意义(P<0.05).治疗前,两组贝克-拉范深躁狂量表(BRMS)、阳性与阴性症状量表(PANSS)评分比较,组间差异无统计学意义(P>0.05);治疗后,观察组BRMS、PANSS评分为(7.98±1.13)分、(39.88±4.52)分,均低于对照组的(12.54±2.36)分、(46.87±5.03)分,组间差异有统计学意义(P<0.05).两组不良反应发生率相比,差异无统计学意义(P>0.05).结论BD躁狂发作患者采用喹硫平联合碳酸锂治疗,可增强效果,减轻临床症状,安全可靠.
Objective To investigate the clinical effect of quetiapine combined with lithium carbonate on manic episode of bipolar disorder(BD).Methods 80 patients with manic episode of BD admitted to our hospital from January to December 2020 were selected and divided into two groups according to random number table.The control group(n=40)was treated with lithium carbonate orally,and the observation group(n=40)was treated with quetiapine on the basis of the control group,with both interventions for 4 weeks.The clinical efficacy,clinical symptom and adverse reactions of the two groups were compared.Results The total effective rate of treatment of the observation group was 92.50%,higher than 75.00%of the control group,with statistically significant difference(P<0.05).There was no significant difference in Bech-Rafaelsen mania scale(BRMS)and positive and negative syndrome scale(PANSS)scores between the two groups before treatment(P>0.05);after treatment,the BRMS and PANSS scores in the observation group were(7.98±1.13)points and(39.88±4.52)points,which were lower than(12.54±2.36)points and(46.87±5.03)points in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of quetiapine and lithium carbonate in patients with manic episode of BD can enhance the effect,and reduce clinical symptoms,which is safe and reliable.
作者
莫燕青
叶秀儿
MO Yanqing;YE Xiu'er(Department of Psychiatry,Dongguan Seventh People's Hospital,Dongguan Guangdong,523230,China)
出处
《反射疗法与康复医学》
2022年第17期117-119,142,共4页
Reflexology And Rehabilitation Medicine
关键词
双相情感障碍
躁狂
喹硫平
碳酸锂
不良反应
Bipolar disorder
Mania
Quetiapine
Lithium carbonate
Adverse reactions
