摘要
目的:了解首都医科大学附属北京安定医院(以下简称"我院")住院精神疾病患者抗精神病药使用现状,为临床合理用药提供依据。方法:以2017年1月至2019年6月我院普通精神科住院精神疾病患者抗精神病药医嘱为依据,分析患者人口学资料、不同年龄段患者使用抗精神病药的种类分布、单一抗精神病药使用种类及频率、不同年龄和性别患者抗精神病药使用剂量等,探讨住院患者抗精神病药的使用特点。结果:共纳入1743例住院精神疾病患者,使用频率排序居前5位的抗精神病药依次为利培酮、奥氮平、喹硫平、阿立哌唑和帕利哌酮;单一抗精神病药使用频率排序居前3位的药品依次为利培酮、奥氮平和喹硫平。青少年患者使用利培酮、奥氮平、喹硫平和帕利哌酮的剂量显著高于中老年患者;男性患者使用利培酮、奥氮平、喹硫平和阿立哌唑的剂量显著高于女性。结论:住院精神疾病患者使用的抗精神病药主要为非典型抗精神病药,以利培酮、喹硫平和奥氮平为主;不同年龄、不同性别患者抗精神病药的使用剂量不同。
OBJECTIVE:To investigate the application of antipsychotic drugs in inpatients with mental disorders in Beijing Anding Hospital,Capital Medical University(hereinafter referred to as"our hospital",so as to provide references for clinical rational medication.METHODS:Based on the medical orders of antipsychotic drugs for inpatients with mental disorders in the general psychiatric department of our hospital from Jan.2017 to Jun.2019,the demographics,distribution of categories of antipsychotic drugs used by patients at different ages,types and frequency of the application of single antipsychotic drugs,dosages of antipsychotic drugs for patients with different ages and genders were analyzed,so as to probe into the characteristics of antipsychotic drugs used in inpatients.RESULTS:A total of 1743 inpatients with mental disorders were involved,the top 5 antipsychotic drugs ranked by frequency of application were respectively risperidone,olanzapine,quetiapine,aripiprazole and paliperidone;the top 3 single antipsychotic drugs ranked by frequency of application were respectively risperidone,olanzapine and quetiapine.The dosages of risperidone,olanzapine,quetiapine and paliperidone in adolescent patients were significantly higher than that in middle-aged and elderly patients;the dosage of risperidone,olanzapine,quetiapine and aripiprazole in male patients was significantly higher than that in female patients.CONCLUSIONS:The antipsychotic drugs applied in inpatients with mental disorders are mainly atypical antipsychotic drugs,including risperidone,quetiapine and olanzapine;the dosage of antipsychotic drugs differs from patients with different ages and genders.
作者
庄红艳
刘珊珊
果伟
鲍爽
ZHUANG Hongyan;LIU Shanshan;GUO Wei;BAO Shuang(Dept.of Medicine,Beijing Anding Hospital,Capital Medical University,the National Clinical Research Center for Mental Disorders&Beijing Key Laboratory for Mental Disorders,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China)
出处
《中国医院用药评价与分析》
2020年第2期232-234,238,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
国家自然基金面上项目(No.81873398)
首都卫生发展科研专项项目(No.首发2018-4-2124)
首都卫生发展科研专项重点攻关项目(No.首发2018-1-2122)
北京中医药科技发展资金项目(No.JJ2018-42)
北京双领学者西学中高级研修项目(资助单位:北京市中医管理局)
北京市医院管理中心“登峰”计划专项经费(No.DFL20191901).
关键词
抗精神病药
精神疾病
住院患者
Antipsychotic drugs
Mental disorders
Inpatients
