摘要
目的:探讨首次发病的精神分裂症患者短期非典型抗精神病药治疗后认知功能的变化。方法:45例首次发作的精神分裂症患者(患者组)给与非典型抗精神病药单药治疗8周;治疗前后给予简明精神病评定量表(BPRS)、公认认知成套测验(MCCB)进行临床及认知功能评估,结果与48名人口学资料相匹配的健康对照者(正常对照组)比较。结果:患者组29例完成8周治疗,治疗后BPRS评分较治疗前显著降低(t=6.87,P<0.01);治疗前MCCB中信息处理速度、注意/警觉、工作记忆、词语学习、视觉学习、推理与问题解决的得分显著低于正常对照组(t=2.33~4.45,P均<0.05);治疗8周后MCCB中注意/警觉得分和工作记忆得分较治疗前明显提高(t=2.80,t=2.16,P均<0.05)。结论:短期非典型抗精神病药治疗精神分裂症首发患者临床症状有明显缓解,但认知功能无明显改善。
Objective： To explore the change of cognitive function in first-episode schizophrenia patients after short-term atypical antipsyehotic medication. Method： sforty five first-episode schizophrenia patients and 48 demographically matched healthy controls were included. All patients were assessed by brief psychiatry rating scale （BPRS） before and after medication. MATRICS consensus cognitive battery （MCCB） were used to assess the cognitive function of all participants. Results：29 patients had completed8-week atypical antipsy- chotie medication. While 11 patients were medicated with risperidone ,9 with olanzapine ,9 with aripiprazole. Pa- tientsBPRS scores declined significantly after medication （t = 6. 87 ,P 〈 0.01 ）. Before medication, the processing speed, attention/vigilance, working memory, verbal learning, visual learning and reasoning ＆ problem solving domain scores of schizophrenia patients are significantly lower than healthy ＂controls （ t = 2.33 - 4.45, all P 〈 0.05 ）. But after medication, patients＂ attention/vigilance score and working memory score raised significantly（ t = 2. 80,t =2.16,all P 〈0.05）. Conclusion： The cognitive function of first-episode schizophrenia patients did not change significantly after short-term antipsyehotie medication.
出处
《临床精神医学杂志》
2017年第2期129-130,共2页
Journal of Clinical Psychiatry
基金
青岛市医药科研指导计划(2016-WJZD068)
