摘要
目的通过对原发性失眠(primary insomnia,PI)患者海马功能连接的研究,探讨其学习能力下降的机制。方法对40例PI患者和50例健康受试者行WHO-UCLA词语学习测定和静息态功能磁共振扫描,以左、右海马为种子点进行全脑功能连接,行组间比较。结果 PI组WHO-UCLA词语学习能力明显低于健康组(P<0.05)。PI组右侧海马与左边缘叶、右丘脑、左脑干连接增强(P<0.05)。左海马与双丘脑功能连接增强(P<0.05)。结论 PI组存在词语学习能力下降,其海马区与双丘脑、左缘上回、左脑干功能连接增强,可能是其学习能力下降的机制。
Objective To explore damage mechanism of learning ability in primary insomnia by the changes of WHO-UCLA word study and the Functional connectivity on hippocampus with the whole brain. Method The WHO-UCLA word learning were applied to evaluate the word study ability for 40 primary insomniacs and 50 healthy subjects,and took a fMRI on the whole brain in a resting state with left and right hippocampus as the seed points to establish functional connection with other encephalic regions,followed by a comparison of the test results of the two groups. Results The WHO-UCLA word learning of PI patients were significantly lower than those of the HC group. The right hippocampus of PI patients showed strengthened functional connection with the left limbic lobe,the right thalamus and the left brainstem. The left hippocampus of PI patients displayed enhanced functional connection with the bilateral thalamus. Conclusion The ability of the PI patients on the WHO-UCLA word study decline. The patients hippocampus have a stronger functional connection with bilateral thalamus,left limbic lobe,left brainstem,which may be the mechanism leading to the learning ability damage of PI patients.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2014年第10期923-925,共3页
Journal of Apoplexy and Nervous Diseases
基金
国家"863"计划资助项目(2012AA011603)
河南省科学技术厅科技计划项目(132102610197
1321023100633)
河南省卫生厅重大科技项目(201202023)
关键词
原发性失眠
静息态
功能磁共振
学习
海马
Primary insomnia
Resting state
Functional MRI
Learning ability
Hippocampus
