摘要
目的:对比右美托咪定与咪达唑仑治疗脓毒症的临床效果。方法:选取2021年1月—2023年1月廉江市人民医院收治的脓毒症患者100例为研究对象,根据随机数字表法分为右美托咪定组和咪达唑仑组,各50例。右美托咪定组给予右美托咪定静脉泵入治疗,咪达唑仑组给予咪达唑仑静脉泵入。比较两组患者用药前后血清炎性指标、心功能指标、躁动-镇静程度评估表(RAAS)评分和不良反应发生率。结果:治疗后,两组血清降钙素原、C反应蛋白、心肌肌钙蛋白T及氨基末端B型钠尿肽前体水平均下降,右美托咪定组低于咪达唑仑组,差异有统计学意义(P<0.05);停药后30 min,两组RASS评分均下降,右美托咪定组低于咪达唑仑组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:与咪达唑仑相比,给予脓毒症患者静脉泵入右美托咪定可显著降低血清炎性因子水平,促进心功能指标恢复,镇静程度更优,且不会增加不良反应。
Objective:To compare the clinical effect of dexmedetomidine and midazolam in the treatment of sepsis.Methods:A total of one hundred patients with sepsis admitted to Lianjiang People's Hospital from January 2021 to January 2023 were selected as the study objects,and were divided into dexmedetomidine group and midazolam group according to random number table method,with fifty patients in each group.Dexmedetomidine group was given intravenous dexmedetomidine and midazolam group was given intravenous midazolam.Serum inflammatory index,cardiac function index,Richmond Agitation-Sedation Scale(RAAS)score before and after treatment and incidence of adverse reactions were compared between the two groups.Results:After treatment,serum levels of procalcitonin,C-reactive protein,cardiac troponin T and amino-terminal B-type natriuretic peptide were decreased in both groups,and dexmedetomidine group was lower than midazolam group,with statistical significance(P<0.05);30 min after drug withdrawal,RASS score of both groups decreased,dexmedetomidine group was lower than midazolam group,the difference was statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compared with midazolam,intravenous injection of dexmedetomidine in sepsis patients can significantly reduce the levels of serum inflammatory factors,promote the recovery of cardiac function indicators,and provide better sedation without increasing adverse reactions.
作者
郑恒
Zheng Heng(Lianjiang People's Hospital,Lianjiang 524400,Guangdong Province,China)
出处
《中外医药研究》
2023年第32期54-56,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
基金
湛江市科学技术局项目(编号:2021B01407)。
关键词
脓毒症
右美托咪定
咪达唑仑
炎性因子
心肌功能
Sepsis
Dexmedetomidine
Midazolam
Inflammatory factors
Myocardial function
