摘要
目的探讨脓毒症休克患者氨基末端脑钠肽前体(NT-proBNP)、C反应蛋白(CRP)、降钙素原(PCT)与APACHEⅡ评分相关性。方法选取2018年6月1日至2020年1月31日阳江市人民医院收治的脓毒症患者70例作为研究对象,根据患者病情的严重程度分脓毒症组(45例)和脓毒症休克组(25例),分析NT-proBNP、CRP、PCT水平与患者预后的相关性。结果脓毒症组患者自入院第1天起,各个时间点APACHEⅡ评分均比前一时间点低,且明显低于脓毒症休克组APACHEⅡ评分,脓毒症组入院第1、7、14天NT-proBNP、CRP、PCT水平均明显低于脓毒症休克组,对比差异均具有统计学意义(P<0.05),相关性分析结果显示NT-proBNP、CRP、PCT表达水平与APACHEⅡ评分呈正相关。结论NT-proBNP、CRP及PCT水平与APACHEⅡ评分密切相关,可以有效评估脓毒性休克患者的预后和病情,其指标升高提示预后不良。
Objective To explore the correlation between N-terminal pro-brain natriuretic peptide(NT-proBNP),C-reactive protein(CRP),procalcitonin(PCT)and APACHEⅡscore in patients with septic shock.Methods Seventy patients with sepsis admitted to Yangjiang People’s Hospital from June 1,2018 to January 31,2020 were selected as the research objects,and according to the severity of the patient′s condition,the sepsis group(45 cases)and the septic shock group(25 cases)were divided,and the correlation between NT-proBNP,CRP,PCT levels and the prognosis of patients was analyzed.Results Since the first day of admission,the APACHEⅡscores of patients in the sepsis group were lower than the previous time point at all-time points,and were significantly lower than the APACHEⅡscores of the septic shock group.The levels of NT-proBNP,CRP and PCT in the sepsis group were significantly lower than those in the septic shock group on the 1,7,and 14 days after admission,and the difference was statistically significant(P<0.05).The Results of correlation analysis showed that the expression levels of NT-proBNP,CRP,PCT were positively correlated with APACHEⅡscore.Conclusion The levels of NT-proBNP,CRP and PCT are closely related to the APACHEⅡscore,which can effectively assess the prognosis and condition of patients with septic shock.An increase in its indicators indicates a poor prognosis.
作者
杨丽萍
陈冬玲
陈金记
何国华
YANG Li-ping;CHEN Dong-ling;CHEN Jin-ji;HE Guo-hua(Yangjiang People’s Hospital,Yangjiang 529500,China)
出处
《延安大学学报（医学科学版）》
2021年第1期73-75,79,共4页
Journal of Yan'an University:Medical Science Edition
