摘要
目的探究老年功能性消化不良(functional dyspepsia,FD)患者应用多潘立酮+复方消化酶治疗的临床价值。方法选取2021年1月—2023年6月镇江市丹徒区人民医院消化内科收治的74例老年FD患者为研究对象,按照随机数表法分为对照组和研究组,每组37例。对照组应用多潘立酮治疗,研究组应用多潘立酮+复方消化酶治疗,对比两组患者临床疗效、症状消失时间、胃动力指标水平、血清指标水平、疼痛评分、生活质量评分及不良反应发生率。结果研究组临床总有效率为94.59%高于对照组的78.38%,差异有统计学意义(χ2=4.163,P<0.05)。研究组的上腹疼痛、灼烧感、反酸症状消失时间均短于对照组,差异有统计学意义(P均<0.05)。治疗前,两组患者胃动素、促肾上腺皮质激素释放激素、胃泌素-17、血清肾蛋白原水平比较,差异无统计学意义(P均>0.05);治疗后,研究组胃动素、胃泌素-17、血清胃蛋白原水平高于对照组,促肾上腺皮质激素释放激素低于对照组,差异有统计学意义(P均<0.05)。治疗前,两组患者疼痛评分、生活质量评分对比,差异无统计学意义(P均>0.05);治疗后,研究组疼痛评分低于对照组,生活质量评分高于对照组,差异有统计学意义(P均<0.05)。对照组不良反应发生率为13.51%与研究组的5.41%对比,差异无统计学意义(P>0.05)。结论多潘立酮+复方消化酶对老年FD患者治疗,胃肠动力改善理想,缩短了症状消失时间,安全性较高。
Objective To explore the clinical value of domperidone plus compound digestive enzymes in elderly pa⁃tients with functional dyspepsia(FD).Methods A total of 74 elderly FD patients admitted to the Department of Gastro⁃enterology,People's Hospital of Dantu District,Zhenjiang City from January 2021 to June 2023 were selected as the research objects.According to the random number table method,they were divided into control group and study group,with 37 cases in each group.The control group was treated with domperidone,and the study group was treated with domperidone+compound digestive enzyme.The clinical efficacy,symptom improvement time,gastric motility index level,serum index level,pain score,quality of life score and incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the study group was 94.59%,which was higher than that of the control group's 78.38%,the difference was statistically significant(χ2=4.163,P<0.05).The disappearance time of upper abdominal pain,burning sensation,and acid reflux symptoms in the study group were shorter than those in the control group, and the differences were statistically significant (all P<0.05). Before treatment, there were no statisti⁃ cally significant differences in the levels of motilin, adrenocorticotropin-releasing hormone, gastrin-17, and serum re⁃ ninogen between the two groups of patients (all P>0.05);after treatment, the levels of motilin, gastrin-17, serun renino⁃ gen of the study group were higher than those of the control group, and the levels of corticotropin releasing hormone were lower than those in the control group, the differences were statistically significant (all P<0.05). Before treatment, there were no statistically significant difference in pain scores and quality of life scores between the two groups of pa⁃ tients (both P>0.05);after treatment, the pain score of the study group was lower than that of the control group, and the quality of life score was higher than that of the control g
作者
周天
蔡宝晶
朱小进
ZHOU Tian;CAI Baojing;ZHU Xiaojin(Department of Gastroenterology,Dantu District People's Hospital,Zhenjiang,Jiangsu Province,212000 China;De-partment of Pharmacy,Shangdang Town Health Center,Zhenjiang,Jiangsu Province,212000 China)
出处
《系统医学》
2023年第24期89-93,共5页
Systems Medicine
关键词
多潘立酮
复方消化酶
老年功能性消化不良
胃肠动力
症状改善
Domperidone
Compound digestive enzyme
Functional dyspepsia in elderly
Gastrointestinal motility
Symptom improvement
