摘要
目的:探讨头孢哌酮舒巴坦分别联合莫西沙星、亚胺培南西司他丁治疗耐碳青霉烯类鲍曼不动杆菌(CRAB)肺炎的效果及对炎症反应的影响。方法:回顾性分析2022年1月至2023年6月于该院治疗的80例CRAB肺炎患者的资料,将2022年1—9月以方便抽样法抽取的40例患者设为A组,采用头孢哌酮舒巴坦联合莫西沙星治疗;将2022年10月至2023年6月以方便抽样法抽取的40例患者设为B组,采用头孢哌酮舒巴坦联合亚胺培南西司他丁治疗。比较两组患者的疗效、细菌清除效果、各项指标恢复时间、血清炎症指标及药品不良反应(ADR)发生情况。结果:B组患者的总有效率、细菌清除率分别为95.00%(38/40)、90.00%(36/40),明显高于A组的80.00%(32/40)、72.50%(29/40),差异均有统计学意义(P<0.05)。B组患者胸部CT恢复正常时间、退热时间和白细胞计数恢复正常时间短于A组,差异均有统计学意义(P<0.05)。治疗2周后,两组患者血清肿瘤坏死因子α(TNF-α)、降钙素原(PCT)及白细胞介素6(IL-6)水平低于治疗前,且B组患者TNF-α、PCT及IL-6水平低于A组,差异均有统计学意义(P<0.05)。B组患者ADR总发生率为12.50%(5/40),与A组的17.50%(7/40)比较,差异无统计学意义(P>0.05)。结论:头孢哌酮舒巴坦联合亚胺培南西司他丁治疗CRAB肺炎的效果优于头孢哌酮舒巴坦联合莫西沙星,可有效改善患者炎症状况,明显提高细菌清除效果,显著缩短体温、白细胞计数等指标恢复时间,且ADR较少。
OBJECTIVE:To probe into the efficacy of cefoperazone sulbactam respectively combined with moxifloxacin and imipenem cilastatin in the treatment of carbapenem-resistant Acinetobacter baumannii(CRAB)pneumonia and its effects on inflammatory reaction.METHODS:Data of 80 patients with CRAB pneumonia admitted into the hospital from Jan.2022 to Jun.2023 were retrospectively analyzed,40 cases from Jan.to Sept.2022 were selected via convenience sampling method to be set as group A,which was given cefoperazone sulbactam combined with moxifloxacin;40 cases from Oct.2022 to Jun.2023 were selected via convenience sampling method to be set as group B,which was given cefoperazone sulbactam combined with imipenem cilastatin.The efficacy,bacterial clearance effect,recovery time of various indicators,indicators of serum inflammation and incidences of adverse drug reactions(ADR)were compared between two groups.RESULTS:The total effective rate and the bacterial clearance rate of group B were respectively 95.00%(38/40)and 90.00%(36/40),significantly higher than 80.00%(32/40)and 72.50%(29/40)of group A,with statistically significant differences(P<0.05).The recovery time of chest CT,time of fever remission and recovery time of white blood cell count of group B were shorter than those of group A,with statistically significant differences(P<0.05).After 2 weeks of treatment,the serum tumor necrosis factorα(TNF-α),procalcitonin(PCT)and interleukin 6(IL-6)levels of both groups were lower than those before treatment,the TNF-α,PCT and IL-6 levels of group B were lower than those of group A,with statistically significant differences(P<0.05).The incidence of ADR was 12.50%(5/40)in group B and 17.50%(7/40)in group A,the difference was not statistically significant(P>0.05).CONCLUSIONS:The efficacy of cefoperazone sulbactam combined with imipenem cilastatin in the treatment of CRAB pneumonia is better than that of cefoperazone sulbactam combined with moxifloxacin,which can effectively improve patients inflammation,obviously promote bacterial cl
作者
庞茜茜
刘斐
蒲洁琨
赵学萍
姜爱雯
齐迎菲
PANG Qianqian;LIU Fei;PU Jiekun;ZHAO Xueping;JIANG Aiwen;QI Yingfei(Dept.of Pharmacy,the First Affiliated Hospital of Hebei North University,Hebei Zhangjiakou 075000,China;Dept.of Intensive Care Unit,the First Affiliated Hospital of Hebei North University,Hebei Zhangjiakou 075000,China)
出处
《中国医院用药评价与分析》
2024年第2期176-179,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
河北省2023年度医学科学研究课题计划项目(No.20231455)。
