摘要
目的 布地奈德雾化联合莫西沙星治疗支原体肺炎的临床疗效观察。方法 选择2021年1月—2022年9月本院收治的106例支原体肺炎患者作为研究对象,随机数表法分为研究组和常规组两组,每组各53例。常规组患者接受阿奇霉素治疗;研究组采用布地奈德雾化联合阿奇霉素、莫西沙星溶液治疗。比较两组患者临床疗效、不良反应发生率以及症状消失时间;对比两组患者治疗前后白介素-6(IL-6)、肿瘤标志物-α(TNF-α)、降钙素原(PCT)。结果 研究组患者治疗总有效率为98.11%(52/53),高于常规组的86.79%(46/53),差异具有统计学意义(P<0.05);研究组患者不良反应发生率为5.66%(3/53),与常规组患者3.77%(2/53)相比,差异无统计学意义(P>0.05);研究组患者体温恢复正常时间、咳嗽消失时间以及肺湿罗音消失时间相较于常规组患者更短,差异均具有统计学意义(P<0.05);两组患者治疗后较治疗前IL-6、TNF-α和PCT水平均显著降低,且研究组的IL-6、TNF-α和PCT水平相较于常规组更低,差异具有统计学意义(P<0.05)。结论 布地奈德雾化联合阿奇霉素、莫西沙星治疗支原体肺炎的临床疗效较好,症状消失时间明显缩短。
Objective To observe the clinical efficacy of budesonide nebulization combined with moxifloxacin in the treatment of mycoplasma pneumonia.Methods One hundred and six patients with mycoplasma pneumonia who were admitted to our hospital from January 2021 to September 2022 were enrolled as study objects,and they were classified into two groups according to the random number table method,with 53 cases in each group.Patients in the routine group received Azithromycin treatment;The study group was treated with Budesonide atomization combined with Azithromycin and Moxifloxacin solution.Then the clinical efficacy,adverse reaction rate,time of symptom disappearance and serum levels of interleukin-6(IL-6),tumor necrosis marker-α(TNF-α)and procalcitonin(PCT)were compared between two groups.Results The overall efficacy rate was 98.11%(52/53)in study group,which was notably higher than 86.79%(46/53)in routine group,with statistical difference(P<0.05).The adverse reaction rate was 5.66%(3/53)in study group,which yielded no statistical difference with 3.77%(2/53)in routine group(P>0.05).The time to normalization of body temperature,disappearance of cough and disappearance of pulmonary rales were significantly shorter in study group than in routine group,with statistical difference(P<0.05).A significant reduction in serum levels of IL-6,TNF-αand PCT were detected in both groups after treatment(P<0.05),and the three inflammation factors of study group were notably lower than those of routine group(P<0.05).Conclusions The clinical efficacy of Budesonide atomization combined with Azithromycin and Moxifloxacin in the treatment of mycoplasma pneumonia is relatively good,and the time of symptom disappearance is significantly shortened.
作者
徐红利
Xu Hongli(Department of Pharmacy,Chest Hospital Affiliated to Zhengzhou University&Henan Provincial Chest Hospital,Zhengzhou,Henan 450000,China)
出处
《齐齐哈尔医学院学报》
2023年第22期2146-2149,共4页
Journal of Qiqihar Medical University
关键词
布地奈德
莫西沙星
支原体肺炎
临床疗效
Budesonide
Moxifloxacin
Mycoplasma pneumonia
Clinical efficacy
