摘要
目的分析无锡地区女性患者阴道分泌物检出的念珠菌种类和耐药情况,初步了解近年来无锡地区女性患者阴道念珠菌种类及耐药情况的变化,为临床合理抗真菌治疗提供参考依据。方法选取2018年1月至2020年12月无锡市妇幼保健院收治的进行阴道分泌物培养且念珠菌检测阳性患者的阴道分泌物标本进行回顾性分析,探讨近年来真菌种类变化趋势及耐药情况。结果2018—2020年分别检出念珠菌2963株、3499株和3274株,其中白色念珠菌分别为2329株(78.6%)、2687株(76.8%)和2467株(75.3%)。念珠菌的药敏结果显示,对几种念珠菌耐药率最高的抗菌药物是益康唑和咪康唑,耐药率最低的抗菌药物是制霉菌素和两性霉素B,几乎没有出现耐药株。结论白色念珠菌是真菌性阴道炎的主要致病菌,白色念珠菌和克柔念珠菌的占比逐年下降,热带酵母菌和光滑酵母菌占比逐年上升。生殖道感染念珠菌对几种常用抗菌药物的耐药情况日益突出,其中热带念珠菌、光滑念珠菌和克柔念珠菌对几种常用抗真菌药物的耐药率高。临床需减少经验性用药,应结合药敏结果提供个性化治疗方案,合理使用抗生素,必要时联合使用多种抗生素治疗,从而减缓耐药菌株的产生速度。
Objective To analyze the candida species and drug resistance detected in vaginal secretions of female patients in Wuxi area,and to preliminarily understand the changes of candida species and drug resistance of female patients in Wuxi area in recent years,so as to provide a reference for rational clinical rational antifungal treatment.Methods Vaginal secretions of patients who were cultured with vaginal secretions and identified as positive candida in Wuxi Maternal and Child Health Hospital from January 2018 to December 2020 were retrospectively analyzed to explore the change trend and drug resistance of fungal species in recent years.Results From 2018 to 2020,2,963,3,499 and 3,274 strains of candida were detected,among which 2,329(78.6%),2,687(76.8%),and 2,467(75.3%)were candida albicans.Through the drug sensitivity results of candida,it was found that the antibacterial drugs with the highest drug resistance rate to candida were econazole and miconazole,and the antibacterial drugs with the lowest drug resistance rate were nysatin and amphotericin B,and almost no drug-resistant strains were found.Conclusions Candida albicans is the main pathogenic bacteria of fungal vaginitis.The proportion of candida albicans and candida krusei decreased year by year,while the proportion of tropical yeast and smooth yeast increased year by year.The drug resistance condition of candida infected with reproductive tract to several commonly used antimicrobial drugs becomes increasingly prominent.Among them,candida tropicalis,candida glabrata and candida krusei show high resistance to several commonly used antifungal drugs.These are an urgent need to reduce the empirical clinical drug use,personalized treatments should be provided in combination with drug sensitivity results,antibiotics should be used rationally,and multiple antibiotics should be used in combination when necessary,so as to slow the production rate of drug-resistant strains.
作者
蒋其
鲍俊峰
王晶
陈月娟
JIANG Qi;BAO Junfeng;WANG Jing;CHEN Yuejuan(Department of Clinical Laboratory,Affiliated Women′s Hospital of Jiangnan University,Wuxi Maternity and Child Health Care Hospital,Wuxi 214002,Jiangsu,China)
出处
《中国性科学》
2024年第2期45-48,共4页
Chinese Journal of Human Sexuality
基金
国家自然科学基金青年项目(81701635)。
关键词
真菌性阴道炎
念珠菌
耐药率
Fungal vaginitis
Candida
Drug resistance rate
