摘要
目的探讨肠内营养粉对老年稳定期慢性阻塞性肺疾病(COPD)患者营养指标及体液免疫功能的影响。方法选取老年稳定期COPD患者116例,根据微型营养评估(MNA)评分将其分为营养正常组(MNA评分>23.5分,24例)、营养不良风险组(17.0分≤MNA评分≤23.5分,65例)和营养不良组(MNA评分<17.0分,27例)。将MNA评分≤23.5分的92例患者随机分为试验组(46例)和对照组(46例)。根据MNA评分,将试验组再分为营养不良风险亚组(17.0分≤MNA评分≤23.5分)33例和营养不良亚组(MNA评分<17.0分)13例。对照组患者常规治疗,试验组在对照组治疗方案基础上予肠内营养粉,两组患者均连续治疗3个月。收集所有患者一般资料、实验室检查指标及肱三头肌皮褶厚度(TSF)、MNA评分并分组进行比较。采用Pearson相关分析评估COPD患者营养及体液免疫指标与MNA评分的相关性。结果营养不良组、营养不良风险组及营养正常组患者BMI、白蛋白、前白蛋白水平及TSF均依次升高(P<0.05)。对照组患者治疗3个月后BMI、IgA水平、TSF及MNA评分均低于同组治疗前,试验组患者BMI、淋巴细胞计数、白蛋白、前白蛋白、IgG水平、TSF及MNA评分均高于同组治疗前;试验组患者治疗3个月后IgG水平及TSF均高于同期对照组(P<0.05)。试验组营养不良亚组及营养不良风险亚组治疗3个月后BMI、淋巴细胞计数、白蛋白、前白蛋白、IgG水平、TSF及MNA评分均高于同组治疗前(P<0.05)。Pearson相关分析结果显示,COPD患者MNA评分与BMI、白蛋白、前白蛋白及TSF均呈显著正相关(P<0.001)。结论肠内营养粉可改善老年稳定期营养不良COPD患者营养状态及IgG水平。
Objective To explore the effect of enteral nutrition powder on nutritional indexes and humoral immune function in elderly patients with stable chronic obstructive pulmonary disease(COPD).Methods A total of 116 elderly patients with stable COPD were selected.According to the Mini nutritional assessment(MNA)score,they were divided into normal nutrition group(MNA score>23.5 points,24 cases),malnutrition risk group(17.0 points≤MNA score≤23.5 points,65 cases)and malnutrition group(MNA score<17.0 points,27 cases).92 patients with MNA score≤23.5 points were randomly divided into experimental group(46 cases)and control group(46 cases).According to MNA score,experimental group was further divided into malnutrition risk subgroup(17.0 points≤MNA score≤23.5 points,33 cases)and malnutrition subgroup(MNA score<17.0 points,13 cases).Patients in control group were given routine treatment,and patients in experimental group were given enteral nutrition powder on the basis of the treatment plan of the control group.Both groups were treated for 3 months.General data,laboratory examination indexes,triceps skinfold thickness(TSF)and MNA score of all patients were collected and compared between groups.Pearson correlation analysis was used to evaluate the correlation between nutritional and cellular immune indexes and MNA score in COPD patients.Results BMI,levels of albumin,prealbumin and TSF in malnutrition group,malnutrition risk group and normal nutrition group were increased in sequence(P<0.05).After 3 months of treatment,BMI,IgA level,TSF and MNA score of control group were lower than those before treatment,while BMI,lymphocyte count,albumin,prealbumin,IgG level,TSF and MNA score of experimental group were higher than those before treatment;IgG level and TSF in experimental group were higher than those in control group after 3 months of treatment(P<0.05).BMI,levels of lymphocyte count,albumin,prealbumin,IgG,TSF and MNA score in malnutrition subgroup and malnutrition risk subgroup of experimental group after 3 months of tr
作者
张美凤
周倩
聂晓红
李垠垠
杨宗艳
张剑虹
马丽
Zhang Meifeng;Zhou Qian;Nie Xiaohong;Li Yinyin;Yang Zongyan;Zhang Jianhong;Ma Li(Department of Pulmonary and Critical Care Medicine,the Second Affiliated Hospital of Chengdu Medical College(the 416 Hospital of Nuclear Industry),Chengdu 610051,China)
出处
《临床内科杂志》
CAS
2023年第12期833-836,共4页
Journal of Clinical Internal Medicine
基金
四川养老与老年健康协同创新中心科研项目(YLZBZ2026)。
关键词
肠内营养粉
慢性阻塞性肺疾病
营养状态
微型营养评估
体液免疫
Enteral nutrition powder
Chronic obstructive pulmonary disease
Nutritional status
Micro nutritional assessment
Humoral immunity
