摘要
子宫肌瘤是女性生殖系统最常见的肿瘤之一。大鼠子宫肌瘤模型是临床前研究的重要载体,对评判药物效能具有重要作用。大鼠子宫肌瘤模型的造模方法以化学诱导法最为常见,此文对化学诱导法中的雌激素单模法,雌孕激素双重造模法,雌孕激素负荷结合多因素刺激法等具体造模方法的差异进行总结,旨在为临床治疗子宫肌瘤提供技术和理论支持。
Uterine fibroids are one of the most common tumors of the female reproductive system.The rat uterine fibroid model is an important carrier for preclinical study and plays an important role in evaluating drug efficacy.The chemical induction method is the most common method for the modeling of rat uterine fibroids.This paper summarized the differences of specific modeling methods in the chemical induction method,including single estrogen modeling method,double estrogen progesterone modeling method,estrogen progesterone loading combined with multi⁃factor stimulation method.The aim is to provide technical land theoretical support for clinical treatment of uterine fibroids.
作者
杨荣兰
李凤灵
魏青
彭必龙
徐萌萌
YANG Ronglan;LI Fengling;WEI Qing;PENG Bilong;XU Mengmeng(The First Clinical Medical College,Guizhou University of Traditional Chinese Medicine,Guizhou Province,Guiyang 550025,China;School of Basic Medicine,Guizhou University of Traditional Chinese Medicine,Guizhou Province,Guiyang 550025,China)
出处
《光明中医》
2024年第2期405-408,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
基金
贵州中医药大学大学生创新创业训练计划省级立项项目(No.贵中医大创合字(2021)99号)。
关键词
癓瘕
子宫肌瘤
动物模型
大鼠
雌激素
孕激素
abdominal mass
uterine fibroids
animal model
rat
estrogen
progesterone
