摘要
目的:探索子宫肌瘤对白介素细胞因子的影响以及三棱莪术组分配伍对子宫肌瘤大鼠相关白细胞介素因子的调控机制。方法:用ELISA法测定子宫肌瘤大鼠血清中IL-1α、IL-1β、IL-4、IL-5、IL-6、IL-7、IL-10、IL-12、IL-13、IL-17、IL-18的表达水平。结果:当给予三棱莪术(S-E)药液及阳性药液干预治疗后,高、中、低剂量组的白介素细胞因子IL-1α、IL-4、IL-5、IL-6、IL-10、IL-12、IL-13、IL-17、IL-18都有不同程度的升高。结论:子宫肌瘤的发生与机体免疫功能的改变有关,三棱莪术可以提升相关白细胞介素水平,调节机体免疫功能,从而达到治疗子宫肌瘤的作用。
Objective:To explore the effects of uterine leiomyoma on interleukin cytokines and the regulatory mechanism of Sangleng and Ezhu component compatibility on related interleukin factors in rats with uterine leiomyoma.Method:The expression levels of IL-1α、IL-1β、IL-4、IL-5、IL-6、IL-7、IL-10、IL-12、IL-13、IL-17 and IL-18 in serum of rats with uterine leiomyoma were measured by ELISA.Result:After the intervention,IL-1α,IL-4,IL-5,IL-6,IL-10,IL-12,IL-13,IL-17 and IL-18in high,medium and low dose groups were increased in varying degrees.Conclusion:The occurrence of uterine leiomyoma was related to the changes in immune function,Sangleng and Ezhu component compatibility improves the level of related interleukin and regulated the immune function,so as to achieve the effect of treating uterine leiomyoma.
作者
张黎
徐秋霞
余成浩
李良文
ZHANG Li;XU Qiu-xia;YU Cheng-hao;LI Liang-wen(School of Basic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan)
出处
《中药与临床》
2022年第1期28-31,共4页
Pharmacy and Clinics of Chinese Materia Medica
基金
国家自然科学基金项目(NO:81673878)
四川省教育厅项目(18ZA0189)。
