摘要
目的探究妊娠糖尿病实施二甲双胍治疗的价值。方法选取2022年9月—2023年9月费县探沂中心医院收治的98例妊娠糖尿病孕妇为研究对象,按照随机掷骰子法分为比照组和调查组,各49例,前者行胰岛素治疗,后者行二甲双胍治疗。比较两组血糖指标、胰岛素功能,统计孕妇并发症发生率,记录新生儿不良结局。结果治疗前,两组血糖和糖化血红蛋白水平比较,差异无统计学意义(P>0.05);治疗后,调查组血糖和糖化血红蛋白水平均低于比照组,差异有统计学意义(P<0.05)。治疗前,两组胰岛素功能指标比较,差异无统计学意义(P>0.05)。治疗后,调查组空腹胰岛素及胰岛素分泌指数高于对比组,而胰岛素抵抗指数低于比照组,差异有统计学意义(P<0.05)。调查组并发症发生率为4.08%低于比照组的18.37%,差异有统计学意义(P<0.05)。调查组不良新生儿结局发生率为6.12%低于比照组的22.45%,差异有统计学意义(P<0.05)。结论二甲双胍能够使血糖得到有效控制,还能改善胰岛素功能,减少孕妇出现的各种并发症,提高新生儿生育质量。
Objective To investigate the value of implementing metformin treatment in gestational diabetes mellitus.Methods From September 2022 to September 2023,98 pregnant women with gestational diabetes mellitus admitted to Fei County Tanyi Central Hospital were selected as the research objects.According to the random roll of the dice,they were divided into the control group and the investigation group,with 49 cases in each group.The former was treated with insulin and the latter with metformin.Blood glucose index and insulin function were compared,the incidence of maternal complications were counted,and adverse neonatal outcomes were recorded.Results Before treatment,there were no differences of blood glucose and glycosylated hemoglobin levels between the two groups(P>0.05);after treat-ment,the blood glucose and glycosylated hemoglobin levels in investigation group were lower than the comparison group,the differences were statistically significant(P<0.05).Before treatment,Comparison of the insulin function mea-sures between the two groups,the differences were not statistically significant(P>0.05).The fasting insulin and insu-lin secretion index in investigation group were higher than the comparison group,while the insulin resistance index was lower than the comparison group,the differences were statistically significant(P<0.05).The complication rate in the investigation group was 4.08%lower than 18.37%in the comparison group,the difference was statistically signifi-cant(P<0.05).The incidence of adverse neonatal outcome in the investigation group was 6.12%lower than 22.45%in the comparison group,the difference was statistically significant(P<0.05).Conclusion Metformin can make effective control of blood glucose,but also improve insulin function,reduce various complications occurring in pregnant women,improve the quality of neonatal births.
作者
张建丽
ZHANG Jiani(Department of Obstetrics and Gynecology,Fei County Tanyi Central Hospital,Linyi,Shandong Province,276000 China)
出处
《糖尿病新世界》
2023年第22期124-127,共4页
Diabetes New World Magazine
关键词
二甲双胍
不良结局
有效率
妊娠糖尿病
Metformin
Adverse outcomes
Efficiency
Gestational diabetes mellitus
