摘要
N6-甲基腺苷(N6-methyladenosine,m6A)是一种可逆的表观遗传修饰,是真核细胞中最丰富的修饰物之一,在信使RNA和非编码RNA中被普遍报道。m6A修饰可调节RNA的转录、加工、剪接、降解和翻译等,在肿瘤生物学行为中发挥重要作用。缺乏5’帽子结构的circ RNA(circular RNA)一直被误认为是转录过程中偶然剪切生成的“垃圾序列”,然而研究发现,circ RNA可以通过micro RNA、结合蛋白、翻译多肽和m6A修饰等多种方式参与肿瘤侵袭和转移。本文就m6A修饰在circ RNA调控作用及其在肝细胞癌中的功能作一综述,并讨论其在该领域的潜在临床应用和可能的未来发展方向。
N6-methyladenosine(m6A)is a reversible epigenetic modification,which is one of the most abundant modifiers in eukaryotic cells,and has been commonly reported in messenger RNAs and non-coding RNAs.The processing modification of m6A regulates RNA transcription,processing,splicing,degradation,and translation,and plays an important role in the biological process of tumors.Circular RNA,which lacks the 5'cap structure,has been mistakenly regarded as a"junk sequence"generated by accidental shearing during the transcription process.However,it has been found that circRNAs can be involved in tumor invasion and metastasis through microRNAs,binding proteins,translated peptides,and m6A modifications.In this paper,we reviewed the role of m6A modifications in circRNA regulation and their functions in hepatocellular carcinoma,and discussed their potential clinical applications and future development in this field.
作者
褚凤冉
刘路政
武金才
CHU Feng-ran;LIU Lu-zheng;WU Jin-cai(Clinical College of Hainan Medical University,Haikou 571199,China;Department of Interventional Vascular Surgery,the Second Affiliated Hospital of Hainan Medical University,Haikou 570216,China;Department of Hepatobiliary and Pancreatic Surgery,Hainan Affiliated Hospital of Hainan Medical University,Hainan General Hospital,Haikou 570311,China)
出处
《海南医学院学报》
CAS
北大核心
2024年第2期155-160,共6页
Journal of Hainan Medical University
基金
海南省重点项目研发计划(ZDYF2020134,ZDYF2022SHFZ283)
海南省自然科学基金(821QN391)。
关键词
N6-甲基腺苷
环状RNA
修饰
肝细胞癌
N6-methyladenosine
Circular RNA
Modification
Hepatocellular carcinoma
