摘要
空间导航活动时刻在我们的生活中发生,导航能力在人群中表现出显著的个体差异,其衰退也是阿尔兹海默症等认知障碍脑疾病的重要早期行为学表现。以往研究考察了空间导航能力个体差异的认知行为特征和相关神经基础,但关于个体差异的成因尚不明确。本研究通过综述近10年的研究进展,从二因素论的视角出发,总结了空间导航个体差异的关键遗传和环境因素及其作用机制,初步建立了空间导航的遗传/环境−大脑网络−认知和行为的通路模型,并对未来发展方向提出展望。该通路模型的完善有助于我们理解空间导航的形成与发展规律,为相关因果机制研究提供理论基础和全面视角,同时对进一步探索空间导航在认知障碍等脑疾病中的潜在临床应用具有重要的应用价值。
Spatial navigation occurs every day in our lives.Decline in spatial navigation is an important early behavioral manifestation of various brain disorders,including Alzheimer's disease(AD).Existing researches have revealed significant individual differences in spatial navigation.However,the biological and environmental origins of such differences are not well defined.From a multi-scale perspective,we reviewed the latest studies on this important topic,and proposed a gene-brain-behavior model for mapping the links between genetic and environmental factors and individual differences in spatial navigation.Integrative analysis of multi-omics and clinical data would be promising for future studies concerning the complex pathways of spatial navigation.Results will help us understand the development patterns of spatial navigation and further explore the potential clinical application relevant brain diseases.
作者
张凤翔
陈美璇
蒲艺
孔祥祯
ZHANG Fengxiang;CHEN Meixuan;PU Yi;KONG Xiang-Zhen(Department of Psychology and Behavioral Sciences,Zhejiang University,Hangzhou 310058,China;Department of Neuroscience,Max Planck Institute for Empirical Aesthetics,Frankfurt am Main 60322,Germany;Department of Psychiatry of Sir Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China)
出处
《心理科学进展》
CSCD
北大核心
2023年第9期1642-1664,共23页
Advances in Psychological Science
基金
中央高校基本科研业务费专项资金(2021XZZX006)
国家自然科学基金(32171031)
科技创新2030(2021ZD0200409)资助。
关键词
空间导航
个体差异
遗传基础
认知地图
环境因素
spatial navigation
individual differences
genetic basis
cognitive map
environmental factors
