摘要
糖尿病是一种成因复杂、累及全身多个器官和系统的代谢性疾病,近年来全世界范围内糖尿病的发病率逐年上升。在中国,仅口服降糖药物或接受胰岛素治疗的糖尿病患者血糖控制效果欠佳。运动是糖尿病初期控制血糖水平的重要手段。鸢尾素(irisin)是一种运动相关的肌肉因子,近年来许多研究发现,2型糖尿病的发生与患者体内irisin水平下降有关。相关机制研究发现,irisin通过预防胰岛素抵抗现象的发生、促进胰岛β细胞的生成以及影响机体糖脂代谢等对糖尿病起到重要的积极作用。此外,irisin水平降低还与多种糖尿病并发症如糖尿病肾病、糖尿病相关心血管疾病等的发生有关。本文总结和分析了irisin在糖尿病发生、发展中的作用及其可能的作用机制,阐述了irisin对多种糖尿病并发症的影响。
Diabetes mellitus is a complex metabolic disease involving multiple organ systems in the body.In recent years,its global incidence rate has increased year by year.In China,the blood glucose control of patients with diabetes mellitus who receive oral hypoglycemic agents or insulin treatment remains poor.In the early disease stages,exercise is important to control blood glucose levels.Recently,many studies have found that the occurrence of type 2 diabetes mellitus was related to declining levels of irisin,an exercise-related muscle factor.Furthermore,studies have found that irisin improved insulin resistance,promoted the production of pancreatic isletβcells,and affected the body’s glucose and lipid metabolism.In addition,its levels were also implicated in the occurrence of various complications,such as diabetic nephropathy and diabetes-related cardiovascular diseases.This article summarizes and analyzes the role of irisin in the occurrence and development of diabetes mellitus and further describes its impact and mechanism on various diabetic complications.
作者
姜禹彤
丁璟
张祎
张艺萍
邱吉巍
魏迎亮
JIANG Yutong;DING Jing;ZHANG Yi;ZHANG Yiping;QIU Jiwei;WEI Yingliang(The Second Clinical College of China Medical University,Shenyang 110004,China;Department of Orthopedics,Shengjing Hospital of China Medical University,Shenyang 110022,China)
出处
《中国医科大学学报》
北大核心
2024年第1期86-90,93,共6页
Journal of China Medical University
基金
国家自然科学基金(31900847)。
关键词
鸢尾素
糖尿病
2型糖尿病
妊娠糖尿病
运动
irisin
diabetes mellitus
type 2 diabetes mellitus
gestational diabetes mellitus
exercise
