摘要
目的:观察戊酸雌二醇片联合米非司酮治疗围绝经期功能失调性子宫出血患者的效果。方法:回顾性分析2020年9月至2022年9月该院收治的128例围绝经期功能失调性子宫出血患者的临床资料,根据治疗方案不同将其分为研究组与对照组各64例。对照组采用米非司酮片治疗,研究组在对照组基础上联合戊酸雌二醇片治疗,比较两组临床疗效、治疗前后子宫内膜厚度、血红蛋白水平、月经量、性激素指标[孕酮、卵泡刺激素(FSH)、雌二醇(E_(2))、黄体生成素(LH)]水平和不良反应发生率。结果:研究组治疗总有效率为95.31%(61/64),高于对照组的79.69%(51/54),差异有统计学意义(P<0.05);治疗后,两组月经量、子宫内膜厚度均低于治疗前,且研究组低于对照组,两组血红蛋白水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组孕酮、FSH、E_(2)、LH水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:戊酸雌二醇联合米非司酮治疗围绝经期功能失调性子宫出血患者可提高治疗总有效率和血红蛋白水平,降低月经量、子宫内膜厚度和性激素指标水平,其效果优于单纯米非司酮片治疗。
Objective:To observe effects of Estradiol valerate tablets combined with Mifepristone in treatment of patients with perimenopausal dysfunctional uterine bleeding.Methods:The clinical data of 128 patients with perimenopausal dysfunctional uterine bleeding admitted to this hospital from September 2020 to September 2022 were retrospectively analyzed.According to different treatment options,they were divided into study group and control group,64 cases in each.The control group was treated with Mifepristone tablets,while the study group was treated with Estradiol valerate tablets on the basis of that of the control group.The clinical efficacy,the endometrial thickness,the hemoglobin level,the menstrual volume,the sex hormone index[progesterone,follicle stimulating hormone(FSH),estradiol(E_(2)),luteinizing hormone(LH)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.31%(61/64),which was higher than 79.69%(51/54)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the menstrual volume and the endometrial thickness of the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the hemoglobin levels of the two groups were higher than those before the treatment,and those in the study group was higher than those in the control group;and the difference was statistically significant(P<0.05).The levels of progesterone,FSH,E_(2) and LH in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Estradiol valerate combined with Mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding can improve the total effect
作者
田会勤
TIAN Huiqin(Department of Obstetrics and Gynecology of Xuchang Beihai Hospital,Xuchang 461000 Henan,China)
出处
《中国民康医学》
2024年第1期69-71,75,共4页
Medical Journal of Chinese People’s Health
关键词
功能失调性子宫出血
围绝经期
戊酸雌二醇片
米非司酮
子宫内膜
性激素
不良反应
Dysfunctional uterine bleeding
Perimenopause
Estradiol valerate tablets
Mifepristone
Endometrium
Sex hormone
Adverse reaction
