摘要
目的观察围绝经期功能失调性子宫出血(DUB)子宫内膜组织中血管内皮生长因子(VEGF)与血管生成素-Ⅱ(Ang-Ⅱ)的表达,探讨其与功血的关系。方法采用免疫组织化学染色观察病理诊断的子宫内膜单纯性增生(120例)、增生期子宫内膜与分泌期子宫内膜(各30例)VEGF与Ang-Ⅱ的表达差异。结果子宫内膜单纯性增生中VEGF与Ang-Ⅱ的表达分别为3.30±2.10、4.67±1.58,增生期分别为2.80±1.66、3.80±2.20,分泌期分别为1.00±0.49、1.80±0.35,即VEGF与Ang-Ⅱ的表达从子宫内膜单纯性增生、增生期到分泌期逐渐降低。结论围绝经期功能失调性子宫出血的发生与子宫内膜局部血管活性物质的改变有关。
Objective To investigate the expression of vascular endothelial growth factor （VEGF） and angiopoietin-Ⅱ （Ang-Ⅱ） in the endometrium of patients with anovulatory dysfunctional uterine bleeding （DUB）. Methods A single-blind randomized controlled clinical trial was conducted. The trial group of 120 cases were diagnosed as endometrial hyperplasia （EH） by curettage underwent pathological examination. Thirty cases with normal proliferative phase and 30 cases with sectetive phase were detected as the control group. VEGF and Ang-Ⅱ expression were examined by immunohistochemistry. Results The expressions of VEGF and Ang-Ⅱ in simple endometrial hyperplasia were 3.30±2.10、4.67±1.58,2.80±1.66、3.80±2.20 in the proliferative endometrial and1.00±0.49、1.80±0.35 in the secreative endometrial. The expressions of VEGF and Ang-Ⅱ in the endometrial hyperplasia were the highest, proliferative endometrial was higher than that of the secreative endometrial. Conclusion The pathogenesis of anovulatory DUB is association with changes of vasoactive substances in the endometrium.
出处
《北京医学》
CAS
2010年第11期877-879,共3页
Beijing Medical Journal
关键词
子宫内膜增生
血管内皮生长因子
血管生成素-Ⅱ
Endometrial hyperplasia Vascular endothelial growth factor（VEGF） Angiopoietin-Ⅱ（Ang-Ⅱ）
