摘要
目的探讨人髓细胞白血病因子1相互作用蛋白基因(MLF1IP)、沉默信息调节因子6(SIRT6)在胃癌组织中的表达及临床意义。方法选取2019年12月至2022年12月本院收治80例胃癌患者的临床病历资料。检测胃癌组织与癌旁组织中MLF1IP、SIRT6的表达情况,分析MLF1IP、SIRT6表达与胃癌临床病理特征的关系。随访并绘制生存曲线。结果癌组织中MLF1IP阳性表达率为65.0%(52/80),高于癌旁组织的31.3%(25/80),差异具有统计学意义(P<0.05);胃癌组织中SIRT6阳性表达率为58.6%(47/80),低于癌旁组织的88.6%(71/80),差异具有统计学意义(P<0.05)。SIRT6表达、MLF1IP表达与年龄、性别、分型、BMI无相关(P>0.05);与TNM分期、病理学分级、肿瘤直径、淋巴结转移、淋巴血管间隙浸润有关(P<0.05)。SIRT6阳性表达组生存率为85.11%(40/47),SIRT6阴性表达组生存率为63.64%(21/33),差异均有统计学意义(P<0.05);MLF1IP阳性表达组生存率为69.23%(36/52),MLF1IP阴性表达组生存率为89.29%(25/28),差异有统计学意义(P<0.05)。结论胃癌组织中MLF1IP表达升高,SIRT6表达降低,且MLF1IP、SIRT6阳性表达与胃癌临床特征存在相关,且MLF1IP、SIRT6表达与胃癌预后生存相关密切。
Objective To investigate the expression and clinical significance of human myeloid leukemia factor 1 interacting protein gene(MLF1IP)and silencing information regulatory factor 6(SIRT6)in gastric cancer tissue.Methods Clinical medical records of 80 gastric cancer patients admitted to our hospital from December 2019 to December 2022 were selected.Detect the expression of MLF1IP and SIRT6 in gastric cancer tissue and adjacent tissues,and analyze the relationship between MLF1IP and SIRT6 expression and clinical pathological characteristics of gastric cancer.Follow up and draw survival curves.Results The positive expression rate of MLF1IP in cancer tissue was 65.0%(52/80),which was higher than 31.3%(25/80)in adjacent tissues,and the difference was statistically significant(P<0.05);The positive expression rate of SIRT6 in gastric cancer tissue was 58.6%(47/80),lower than 88.6%(71/80)in adjacent tissues,and the difference was statistically significant(P<0.05).The expression of SIRT6 and MLF1IP was not correlated with age,gender,subtype,or BMI(P>0.05);It is related to TNM staging,pathological grading,tumor diameter,lymph node metastasis,and infiltration of lymphatic spaces(P<0.05).The survival rate of the SIRT6 positive expression group was 85.11%(40/47),while the survival rate of the SIRT6 negative expression group was 63.64%(21/33),with statistically significant differences(P<0.05);The survival rate of the MLF1IP positive expression group was 69.23%(36/52),while the survival rate of the MLF1IP negative expression group was 89.29%(25/28),with a statistically significant difference(P<0.05).Conclusion The expression of MLF1IP is increased and the expression of SIRT6 is reduced in gastric cancer tissue.The positive expression of MLF1IP and SIRT6 is correlated with the clinical characteristics of gastric cancer,and the expression of MLF1IP and SIRT6 is closely related to the prognosis and survival of gastric cancer.
作者
李杰
侯玮
张燕
常青
LI Jie;HOU Wei;ZHANG Yan;CHANG Qing(Department of Digestive Oncology,Baotou Cancer Hospital,Baotou 014030,China)
出处
《临床肿瘤学杂志》
2023年第10期920-923,共4页
Chinese Clinical Oncology
基金
北京医学奖励基金会资助项目(YXJL-2022-0791-0082)。
关键词
胃癌
人髓细胞白血病因子1相互作用蛋白基因
沉默信息调节因子6
表达
预后
Gastric cancer
Human myeloid leukemia factor 1 interacting protein gene
Silence information regulator 6
Expression
Prognosis
