摘要
目的分析粉尘螨致敏支气管哮喘患儿应用吸入性糖皮质激素(inhaled corticosteroids,ICS)联合运动康复对炎症因子表达的影响。方法选取2019年3月—2022年3月无锡市儿童医院初诊的112例非急性发作期支气管哮喘患儿为研究对象,按随机数表法分为对照组(56例)和研究组(56例)。对照组行ICS治疗,研究组在对照组基础上联合运动康复治疗。治疗1个月后,对比两组临床疗效、肺功能、炎症因子及生活质量。结果研究组总有效率为94.64%较对照组的78.57%更高,差异有统计学意义(χ^(2)=6.235,P<0.05)。治疗后,研究组第1秒用力呼气量、用力肺活量及呼吸流速峰值水平较对照组更高,差异有统计学意义(P<0.05)。治疗后,研究组白细胞介素-6、白细胞介素-18、白细胞介素-5及白细胞介素-18水平较对照组更低,差异有统计学意义(P<0.05)。治疗后,研究组干扰素-γ水平较对照组更高,差异有统计学意义(P<0.05)。治疗后,研究组活动、症状及情感评分较对照组更高,差异有统计学意义(P<0.05)。结论ICS与运动康复联合治疗粉尘螨致敏哮喘患儿,有利于患儿肺功能改善,促进生活质量提高,并下调炎症因子表达。
Objective To analyze the effect of the application of inhaled corticosteroids(ICS)combined with exercise rehabilitation on the expression of inflammatory factors in children with dust mite-sensitized bronchial asthma.Methods 112 children with non acute stage bronchial asthma who were initially diagnosed at Wuxi Children's Hospital from March 2019 to March 2022 were selected as the research subjects.They were randomly divided into a control group(56 cases)and a study group(56 cases)using a random number table method.The control group received ICS treatment,while the study group received combined exercise rehabilitation treatment on the basis of the control group.After one month of treatment,compare the clinical efficacy,lung function,inflammatory factors,and quality of life between the two groups.Results The total effective rate of the research group was 94.64%,which was higher than the control group's 78.57%,and the difference was statistically significant(χ^(2)=6.235,P<0.05).After treatment,the study group had higher peak levels of forced expiratory volume,forced vital capacity,and respiratory flow rate in the first second compared to the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6,interleukin-18,interleukin-5,and interleukin-18 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the level of interferon-γin the research group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the activity,symptoms,and emotional scores of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion The combination of CS and exercise rehabilitation therapy is beneficial for improving lung function,promoting quality of life,and downregulating the expression of inflammatory factors in children with dust mite induced asthma.
作者
沈萍
周琴
蒋熠
SHEN Ping;ZHOU Qin;JIANG Yi(Department of Respiratory Medicine,Children's Hospital Affiliated to Jiangnan University(Wuxi Children's Hospital),Wuxi,Jiangsu Province,214000 China)
出处
《系统医学》
2023年第20期142-145,共4页
Systems Medicine
关键词
吸入性糖皮质激素
运动康复
粉尘螨致敏
支气管哮喘
炎症因子
肺功能
Inhaled glucocorticoids
Exercise rehabilitation
Dust mite-sensitized
Bronchial asthma
Inflammatory factor
Lung function
