摘要
目的探讨肾上腺素能受体β2(ADRB2)和Ⅰ型Fcε受体β(FCER1B)基因多态性与壮族咳嗽变异性哮喘(CVA)患儿治疗效果及肺功能改善情况的相关性。方法纳入88例壮族CVA患儿,检测其ADRB2基因rs1042713位点、FCER1B基因rs569108位点的基因型。随访患儿使用吸入性糖皮质激素治疗3个月后的疗效及肺功能改善情况。分析上述两个基因位点多态性与患儿治疗效果及治疗后肺功能改善情况的相关性。结果88例CVA患儿中,治疗好转67例(好转组)、无效21例(无效组),肺功能正常52例(肺功能正常组)、肺功能异常36例(肺功能异常组)。好转组与无效组之间、肺功能正常组与肺功能异常组之间ADRB2基因rs1042713位点基因型分布的差异均有统计学意义(均P<0.05),携带GG基因型患儿治疗后出现无效、肺功能异常的风险分别是携带AA/AG基因型患儿的4.833倍、7.636倍(均P<0.05)。好转组与无效组之间、肺功能正常组与肺功能异常组之间FCER1B基因rs569108位点基因型分布的差异均无统计学意义(均P>0.05)。结论壮族CVA患儿的吸入性糖皮质激素治疗效果及治疗后肺功能改善情况可能与ADRB2基因rs1042713位点多态性密切相关,而与FCER1B基因rs569108位点多态性可能无关。
Objective To investigate the correlation of adrenoceptor beta 2(ADRB2)and Fc epsilon receptorⅠβ(FCER1B)gene polymorphisms with therapeutic effect and pulmonary function improvement in Zhuang children with cough variant asthma(CVA).Methods A total of 88 Zhuang children with CVA were enrolled,and their genotype of ADRB2 gene rs1042713 locus and FCER1B gene rs569108 locus was detected.The 3-month post-treatment efficacy and pulmonary function improvement of children undergoing inhaled glucocorticoid therapy were followed up.The correlation of the two gene loci polymorphisms as above with therapeutic effect and post-treatment pulmonary function improvement was analyzed.Results Among 88 children with CVA,67 cases presented as improvement(the improvement group),21 cases as ineffectiveness(the ineffective group),52 cases as normal pulmonary function(the normal pulmonary function group),and 36 cases as abnormal pulmonary function(the abnormal pulmonary function group).There were statistically significant differences in genotype distribution of ADRB2 gene rs1042713 locus between the improvement group and the ineffective group,and between the normal pulmonary function group and the abnormal pulmonary function group(all P<0.05).The risk of ineffectiveness and abnormal pulmonary function after treatment in children with GG genotype was 4.833 times and 7.636 times as high as that in children with AA/AG genotype,respectively(all P<0.05).There was no statistically significant difference in genotype distribution of FCER1B gene rs569108 locus between the improvement group and the ineffective group,and between the normal pulmonary function group and the abnormal pulmonary function group(all P>0.05).Conclusion The therapeutic effect and post-treatment pulmonary function improvement of Zhuang children with CVA undergoing inhaled glucocorticoid are closely related to ADRB2 gene rs1042713 locus polymorphism,whereas is possibly not related to polymorphism of FCER1B gene rs569108 locus.
作者
陆玉娇
杨月容
陈宇
罗柳
胡丽珊
米佳
LU Yu-jiao;YANG Yue-rong;CHEN Yu;LUO Liu;Hu Li-shan;Mi Jia(Department of Pediatrics,the First People′s Hospital of Nanning,Nanning 530021,Guangxi,China)
出处
《广西医学》
CAS
2022年第22期2618-2623,共6页
Guangxi Medical Journal
基金
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20200121)。
