摘要
中枢神经系统是一个与麻醉密切相关的复杂系统,许多中枢神经系统疾病的分子生物学机制并不十分清楚。长链非编码RNA(long noncoding RNA,lncRNA)H19在人脑内含量丰富且在多种中枢神经系统疾病中发挥调控作用。同时lncRNA H19也参与调控多种麻醉药物对机体的作用。本文就lncRNA H19在中枢神经系统常见疾病的研究进展进行综述,并结合其在麻醉药物中的研究深入讨论,为进一步探索lncRNA H19在中枢神经系统的作用提供理论依据。
Central nervous system(CNS)is a complex system closely related to anesthesiology.The molecular biological mechanisms of many CNS diseases were not exactly clear.Long noncoding RNA(lncRNA)H19 is abun⁃dant in human brain and plays an important role in the regulation of various CNS diseases.Besides,lncRNA H19 is also involved in the mechanism of several anesthetics.In this review,we emphasized the role and addressed the specific mechanisms of lncRNA H19 in CNS diseases and anesthetics,hoping to provide a new theoretical basis for future researches.
作者
毛元元
袁静静
MAO Yuanyuan;YUAN Jingjing(Department of Anesthesiology,Pain and Perioperative Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《实用医学杂志》
CAS
北大核心
2023年第23期3021-3026,共6页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:82101298)
河南省自然科学基金项目(编号:212300410239)。
