摘要
长链非编码RNA(long non-coding RNA,Lnc RNA)是非编码RNA的重要一员,长度超过200个核苷酸,缺乏开放的阅读框,无编码蛋白质的功能。近年来研究发现Lnc RNA的表达异常与乳腺癌的发生、发展和侵袭转移密切相关。最新研究数据显示,Lnc RNA的组织特异性表达具有区分正常和肿瘤组织甚至乳腺癌不同阶段的潜能,深入研究Lnc RNA在乳腺癌中的机制作用有望对乳腺癌的早期诊断、治疗、预后提供新的思路与方法。
Long non-coding RNA （LncRNA） genes, with more than 200 nucleotides, the lack of an open reading frame （ORF）, and no protein-coding capacity, are an important member of non-coding RNAs. In recent years, many studies have shown that the abnormal expression of LncRNAs plays an important role in tumorigenesis, development, invasion and metastasis, especially in breast cancer. Based on the latest research data, the tissue specific expression signature of LncRNAs may represent a potential to discriminate between normal and tumor tissue or even different stages of breast cancer, which makes them clinically beneficial as possible biomarkers and provide new ideas and methods for early diagnosis,treatment, and prognosis of breast cancer.
出处
《分子诊断与治疗杂志》
2018年第1期61-66,共6页
Journal of Molecular Diagnostics and Therapy
基金
广东省科技计划项目(2014A020212274)
广州市科技计划项目(201510010044)
广东省中医院转化医学专项(YN2014ZHR201)
国家自然科学基金项目(81601736)
