摘要
长链非编码RNA(long noncoding RNA,lncRNA)是一类长度超过200个核苷酸的非编码RNA分子,其数量众多,但缺少蛋白质编码功能。研究发现,lncRNA能在表观遗传学、转录及转录后等多种水平调控基因的表达,在各类生物过程中起着重要的调节作用,并与多种疾病相关,已经成为现代遗传学的研究热点。近期研究证据显示,肺癌中有多种lncRNA的表达水平发生了变化,并在肺癌的发生、发展及预后中起着重要的调控作用。本文就lncRNA的定义、功能机制及与肺癌的相关性研究作一综述。
Long noncoding RNAs（lncRNAs）,contraining more than 200 nucleotides,are RNA transcripts without protein-coding capacity.It has been reported that lncRNAs regulate gene expression at the epigenetic,transcriptional and posttranscriptional levels,and are deeply involved in various biological processes.Many diseases are found related to lncRNAs and they have become a focus of studies.According to recent evidences,a number of lncRNAs are changed in lung cancer,and they play a significant part in the development,progression and prognosis of lung cancer.This review focuses on the definition and functional mechanism of lncRNAs and their relation with lung cancer.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2014年第10期1115-1120,共6页
Academic Journal of Second Military Medical University
基金
国家自然科学基金(81000006)
第二军医大学创新基金重点项目(ZD2013011)
上海市浦江人才计划(14PJ1411000)~~
关键词
长链非编码RNA
肺肿瘤
基因表达调控
long noncoding RNAs
lung neoplasms
gene expression regulation
