摘要
T细胞免疫球蛋白黏蛋白3(TIM-3)基因异常在肿瘤发生发展及预后中起重要作用。研究表明,TIM-3基因在胃癌、大肠癌、肝癌、肺癌等多种肿瘤中表达上调,与肿瘤发生发展及低生存率、易复发、预后差相关。信号转导子和激活子3(STAT3)在细胞生长、增殖、分化和凋亡中起重要作用。STAT3高表达于结直肠腺癌,可诱导肿瘤细胞增殖和分化,抑制肿瘤细胞凋亡,促进肿瘤组织血管生成及肿瘤细胞转移,导致肿瘤恶化。本文对TIM-3及STAT3基因在结直肠癌中的研究进展进行综述。
T-cell immunoglobulin mucin 3(TIM-3)genetic abnormalities play an important role in occurrence,development and prognosis of cancer.Studies have shown that TIM-3 gene was overexpressed in gastric cancer,colorectal cancer,liver cancer,lung cancer and other tumors,which play an important role in development of tumor,and related to low survival rate,recurrence and prognosis of tumor.Signal transducers and activators of 3(STAT3)plays an important role in cell growth,proliferation,differentiation and apoptosis.High activation of STAT3 in colorectal adenocarcinoma induces proliferation and differentiation of tumor cells,inhibits apoptosis of tumor cells,promotes angiogenesis of tumor tissues,and further promotes growth and distant metastasis of tumor cells,and gradually promotes deterioration of tumor.In this review,we will review research progress of TIM-3 and STAT3 genes in colorectal cancer.
作者
李福青
王红(指导)
蒋海涛
杜胜奇
钟江利
LI Fu-Qing;WANG Hong;JIANG Hai-Tao;DU Sheng-Qi;ZHONG Jiang-Li(Department of Gastroenterology,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2020年第15期1917-1920,F0003,共5页
Chinese Journal of Immunology
