摘要
糖尿病肾病(DN)目前被认为是免疫参与的慢性炎症性疾病,炎症反应贯穿于DN的始终。而细胞焦亡作为一种炎症细胞死亡方式同样参与DN的发生发展过程,其通过破坏肾脏固有细胞加重肾脏纤维化、肾小球硬化和肾小管损伤等,促进疾病进展,是重要的发病机制之一。DN细胞焦亡受到炎症、氧化应激、免疫反应、细胞生存、细胞能量代谢等信号通路的调控,涉及核苷酸结合寡聚化结构域样受体蛋白3炎症小体的激活以及消皮素D、胱天蛋白酶1、白细胞介素(IL)-1β、IL-18等焦亡相关因子的过度表达,对具体信号通路的进一步研究有望为DN的防治提供新的治疗靶点。
Diabetic nephropathy(DN)is currently considered as a chronic inflammatory disease involving immunity,and inflammatory reaction runs through the whole process of DN.As a way of inflammatory cell death,pyroptosis also participates in the occurrence and development of DN.It can aggravate renal fibrosis,glomerulosclerosis and tubular damage by destroying the intrinsic cells of the kidney,thus promoting the progress of the disease,which is one of the important pathogeneses of DN.Pyroptosis of DN is regulated by multiple signaling pathways such as inflammation,oxidative stress,immune response,cell survival,and cell energy metabolism,involving the activation of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and the overexpression of multiple pyroptosis-related factors such as gasdermin D,caspase-1,interleukin(IL)-1βand IL-18.Further research on specific signaling pathways is expected to provide new therapeutic targets for the prevention and treatment of DN.
作者
王爽
李小会
林莉
陈丽名
屈杰
WANG Shuang;LI Xiaohui;LIN Li;CHEN Liming;QU Jie(Shaanxi University of Chinese Medicine,Xianyang 712046,China)
出处
《医学综述》
CAS
2023年第23期5169-5174,共6页
Medical Recapitulate
基金
国家自然科学基金(82074383)
伤寒学与经方辨治疑难病一流学科创新团队项目(2019-QN04)
陕西省中医药管理局重点研究室建设项目(陕中医药发〔2018〕32号)。
