摘要
目的研究2型糖尿病(T2DM)患者血清碳水化合物反应元件结合蛋白(ChREBP)水平变化及与糖尿病肾病(DN)的关系。方法选取2016年2月~2018年12月辽宁省阜新市第二人民医院(妇产医院)(以下简称“我院”)收治的T2DM患者193例,根据尿白蛋白肌酐比值(UACR)结果进行分组,UACR≤30的患者为单纯T2DM组(123例),UACR>30的患者为DN组(70例)。另取同期在我院接受体检的50名健康人作为对照组。比较三组临床资料,酶联免疫吸附试验检测血清ChREBP水平,logistic回归分析DN影响因素,受试者工作特征曲线分析血清ChREBP诊断DN的能效。结果DN组糖尿病病程长于T2DM组(P<0.05);T2DM组、DN组的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均高于对照组,而高密度脂蛋白胆固醇(HDL-C)低于对照组(均P<0.05);DN组24 h尿白蛋白排泄率(24 h UAER)、ChREBP水平高于对照组、T2DM组,肾小球滤过率(eGFR)低于对照组、T2DM组(均P<0.05);T2DM组24 h UAER、ChREBP水平高于对照组,eGFR低于对照组(均P<0.05)。糖尿病病程、24 h UAER以及ChREBP均是DN的独立危险因素。截断值为154.36 ng/mL时,灵敏度为0.872,特异度为0.834。结论血清ChREBP水平在DN患者中异常高表达,临床可检测血清ChREBP水平用于早期DN的诊断。
Objective To study the changes of serum carbohydrate response element binding protein(ChREBP)level in patients with type 2 diabetes mellitus(T2DM)and its relationship with diabetic nephropathy(DN).Methods From February 2016 to December 2018,193 cases with T2DM patients who admitted to the Second People′s Hospital and Gynecology and Obstetrics Hospital of Fuxin City of Liaoning Province(“our hospital”for short)were selected.According to the results of urinary albumin creatinine ratio(UACR),the patients whose UACR≤30 were in simple T2DM group(123 cases),and the patients with UACR>30 were in DN group(70 cases),and 50 healthy people receiving physical examination in our hospital during the same period were selected as control group.Clinical data in three group were compared.The serum ChREBP level was detected by enzyme-linked immunosorbent assay and logistic regression analysis was conducted DN influencing factors.The energy efficiency of serum ChREBP in the diagnosis of DN was analyzed by the receiver operating characteristic curve of subjects.Results The duration of diabetes in DN group was longer than that of simple T2DM group(P<0.05).The levels of fasting blood-glucose(FBG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterin(LDL-C)in simple T2DM group and DN group were higher than those of control group,while the level of high density lipoprotein cholesterol(HDL-C)was lower than that of control group(all P<0.05).The 24 h urinary albumin excretion rate(24 h UAER)and ChREBP levels of DN group were higher than those of control group and simple T2DM group,and the glomerular filtration rate(eGFR)was lower than that of control group and simple T2DM group(all P<0.05).The levels of 24 h UAER and ChREBP insimple T2DM group were higher than those in control group,and the eGFR was lower than that in control group(all P<0.05).Duration of diabetes,24 h UAER and ChREBP levels were independent risk factors for DN.The cut-off value was 154.36 ng/mL,the sensitivity
作者
韩兵
陈烨
齐丽
HAN Bing;CHEN Ye;QI Li(Department of Nephrology,the Second People′s Hospital and Gynecology and Obstetrics Hospital of Fuxin City,Liaoning Province,Fuxin123000,China;Department of Nephrology,Fuxin Central Hospital,Liaoning Province,Fuxin123000,China)
出处
《中国医药导报》
CAS
2020年第9期173-176,共4页
China Medical Herald
基金
辽宁省科技计划项目(20160379)。
关键词
2型糖尿病
糖尿病肾病
碳水化合物反应元件结合蛋白
诊断
Type 2 diabetes mellitus
Diabetic nephropathy
Carbohydrate response element binding protein
Diagnosis
