摘要
目的探讨中医康肾4号联合厄贝沙坦治疗2型糖尿病肾病(DN)患者的效果。方法选取该院内分泌科收治的82例DN患者,根据治疗方法分为中西医组和西医组各41例,两组均给予基础降糖、改善肾功能方案治疗,西医组同时服用厄贝沙坦,中西医组同时服用厄贝沙坦+康肾4号治疗;对比两组患者治疗前后的血糖、肾功能、炎性因子指标、中医证候积分、临床疗效差异。结果治疗前,中西医组和西医组患者的空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)测定值比较,差异无统计学意义(P>0.05);治疗后,两组FPG、2 hPG、HbA1c测定值比较,差异统计学意义(P>0.05);治疗前,中西医组和西医组患者的UAER、24 h尿蛋白定量、M/U测定值比较,差异无统计学意义(P>0.05);治疗后,中西医组UAER、24 h尿蛋白定量、M/U低于西医组,差异具有统计学意义(P<0.05);治疗前,中西医组和西医组患者的CysC、hs-CRP测定值比较,差异无统计学意义(P>0.05);治疗后,中西医组CysC、hs-CRP低于西医组,差异具有统计学意义(P<0.05);治疗前,中西医组和西医组患者的主证积分、次证积分、中医证候总分比较,差异无统计学意义(P>0.05);治疗后,中西医组主证积分、次证积分、中医证候总分低于西医组,差异具有统计学意义(P<0.05);治疗后,中西医组的显效率53.66%(22/41)、有效率43.90%(18/41)、无效率2.44%(1/41),西医组的显效率29.27%(12/41)、有效率63.41%(26/41)、无效率7.32%(3/41),中西医组疗效优于西医组(P<0.05)。结论中医康肾4号联合厄贝沙坦治疗DN患者效果可靠,对于改善患者肾功能、中医证候效果显著。
Objective To explore the effect of TCM Shenkang No.4(康肾4号)combined with irbesartan in the treatment of patients with type 2 diabetic nephropathy(DN).Methods Eighty-two patients with DN admitted to the Department of Endocrinology in the hospital were divided into the combination of traditional Chinese and Western medicine group and the Western medicine group according to the treatment methods,41 cases in each group.Both groups were given the basic hypoglycemic and renal function improvement programs.The Western medicine group took irbesartan at the same time.The combination of traditional Chinese and Western medicine group took irbesartan+Shenkang No.4 at the same time.The differences in blood glucose,renal function,inflammatory factor indexes,TCM syndrome scores and clinical efficacy of the two groups before and after treatment were compared.Results Before treatment,there was no significant difference in fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 h PG)and glycosylated hemoglobin type A1 c(HbA1 c)between two groups(P>0.05).After treatment,the difference of FPG,2 h PG and HbA1 c between the two groups was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in urinary albumin ejection rate(UAER),24 h urine protein quantification(24-hUpro)or M/U measurement values of patients in the two groups(P>0.05).After treatment,the UAER,24 h urine protein quantification and M/U in the combination of traditional Chinese and Western medicine group were lower than those of the western medicine group and the difference was statistically significant(P<0.05).Before treatment,the levels of cystatin(CysC)and hypersensitive C-reactive-protein(hs-CRP)in the two groups were not statistically significant(P>0.05).After treatment,the levels of CysC and hs-CRP in the combination of traditional Chinese and Western medicine group were lower than those in the Western medicine group and the difference was statistically significant(P<0.05).Before treatment,there was no sig
作者
哈团结
李中南
孙丽丽
陈秀芝
邹斌
杨真
张帆
HA Tuanjie;LI Zhongnan;SUN Lili;CHEN Xiuzhi;ZOU Bin;YANG Zhen;ZHANG Fan(Taihe Hospital of Traditional Chinese Medicine,Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 236600,Anhui,China;The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230601,Anhui,China)
出处
《辽宁中医杂志》
CAS
2022年第5期91-94,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
中医
康肾4号
厄贝沙坦
糖尿病肾病
traditional Chinese medicine
Shenkang No.4(康肾4号)
irbesartan
diabetic nephropathy
