摘要
目的:探索糖尿病肾病肾功能不全期不同证候和性别、年龄、实验室指标的相关性,试图揭示中医证候的本质。方法:按照课题组统一制定的调查表对糖尿病肾病肾功能不全患者进行调查,采集符合纳入标准的糖尿病肾病患者的一般情况、中医四诊信息以及相关的实验室检查。采用典型相关分析对多项实验室指标与多种中医证型的相关性进行研究。结果:典型相关分析显示,对痰湿证和体质指数,湿浊证和内生肌酐清除率,阴虚证和糖化血红蛋白等3对典型相关系数进行近似F检验,P<0.05,有统计学意义,表明存在相关性。结论:提示形体肥胖之人,其证候类型多偏于痰湿。认为糖尿病肾病中晚期患者普遍存在浊毒内停、气血损伤病机,治疗应重视益气养血、和胃泄浊解毒治法,泄浊毒、护胃气即所以保肾元的治疗思路。再者,认为内热伤阴是糖尿病的基本病机特点,贯穿于糖尿病发生发展的全过程,而血糖控制差的病人其内热的表现会更加明显。提示这3项实验室指标可以作为临床辨证的依据。
Objective： To discuss relativity of different TCM syndrome with sex, age and laboratory indices in 265 cases of diabetic nephropathy renal failure, and this work is meaningful to open out the naure of TCM syndrome. Methods： The research proceeded the questionary of diabetic nephropathy established according to task group.Including commonly instances, four diagnostic methods information of TCM and correlative laboratory indices. Canonical correlative analysis was adopted to research the relativity of laboratory indices with different TCM syndrome. Results： The results of canonical correlative analysis displayed that phlegm-dampness and BMI, dampness-turbid and creatinine clearance rate, deficiency of yin and glycosylated hemoglobin had pertinence （P〈0.05）. Conclusion： The results of canonical correlative analysis displayed that the obesity people mainly belonged to phlegm and dampness, and proved that enriching blood and qi, nourishing stomach, purging turbid and toxin were mainly therapetic pathway in recover period of diabetic nephropathy renal failure.Furthermore, we considered that inner heat was the basic pathogenesis in diabetic mellitus,and the blood sugar control differ would be more obvious.The results hint that these three laboratories indices can be used as the clinical basis of differentiation of syndromes.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2008年第12期1057-1060,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
“十五”国家科技攻关项目(No.2001BA701A13c)
关键词
糖尿病肾病
证候学研究
典型相关性研究
临床研究
Diabetic Nephropathy
TCM syndrome research
Canonical correlative analysis
Clinical research
