摘要
骨骼肌是人体运动系统的主要器官,骨骼肌受损会降低生活质量、加重疾病恶化,探究骨骼肌再生和修复对恢复和维持肌肉功能至关重要。N6-甲基腺苷(N6-methyladenosine,m6A)修饰是真核生物中重要的mRNA甲基化修饰,其在调控骨骼肌生成中的作用与中医药健脾补肾法滋养肌肉生长相契合。本文总结了m6A甲基化修饰相关同源因子甲基转移酶、去甲基化酶和识别蛋白在骨骼肌生成中的作用,并探讨了其与中医理论的相关性,以及中医药疗法在骨骼肌生成中的应用,为深入研究骨骼肌修复与再生的相关分子机制及中医药介导m6A修饰调控骨骼肌生成提供理论依据和研究思路。
Skeletal muscle is the main organ of the human motor system,and damage to skeletal muscle can reduce quality of life and worsen disease.Exploring skeletal muscle regeneration and repair is essential to restore and maintain muscle function.N6-methyladenosine modification is an important mRNA methylation modification in eukaryotes,and its role in regulating skeletal muscle production is compatible with the traditional Chinese medicine invigorating the spleen and tonifying the kidney to nourish muscle growth.This paper summarizes the roles of m6A methylation modification-related homologous factors methyltransferases,demethylases and recognition proteins in myogenesis,and discusses their correlation with traditional Chinese medicine theory and the application of traditional Chinese medicine therapy in myogenesis,which provides theoretical basis and research ideas for in-depth study of the molecular mechanism of skeletal muscle repair and regeneration and traditional Chinese medicine regulates myogenesis through m6A modification.
作者
郝羚伦
彭梦薇
陈玉龙
刘燕
吴耀松
HAO Linglun;PENG Mengwei;CHEN Yulong;LIU Yan;WU Yaosong(Henan Key Laboratory of Traditional Chinese Medicine Syndrome and Prescription Signaling,Henan International Joint Laboratory of Traditional Chinese Medicine Syndrome and Prescription in Signaling,Academy of Chinese Medical Sciences,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China)
出处
《生命的化学》
CAS
2023年第10期1627-1633,共7页
Chemistry of Life
基金
国家自然科学基金项目(82074313)
河南省科技攻关项目(192102310160)
河南省高等学校重点科研项目(23A360024)。
