摘要
骨骼肌拥有良好的再生和损伤后修复能力,这种自我更新的能力依赖于骨骼肌卫星细胞。当肌肉损伤后,骨骼肌卫星细胞从静息状态被激活并开始增殖,进而形成肌前体细胞或成肌母细胞,最终分化成肌细胞,并与原有肌纤维融合修复损伤的肌肉。本文就骨骼肌卫星细胞自我更新的分子调节机制作一综述。
Skeletal muscle possesses a remarkable ability for its regeneration and injured tissue repair.This ability depends on the activity and contributions of muscle satellite cells.Proliferating satellite cells,termed myogenic precursor cells or myoblasts,are activated and driven out of their quiescent state upon muscle injury.In this summary,we present a review to summarize the molecular regulation in skeletal satellite cells to light on the satellite cells＇ self-renewal mechanism.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2014年第5期1168-1171,共4页
Journal of Biomedical Engineering
基金
转基因生物新品种培育科技重大专项基金资助(2011ZX08009-003-006)
关键词
骨骼肌卫星细胞
自我更新
分子调节
skeletal satellite cell
self-renewal
molecular regulation
