摘要
目的研究胃食管反流病(gastroesophageal reflux disease,GERD)患者血清炎症因子水平、P物质(substance P,SP)及降钙素基因相关肽(calcitonin gene-related peptide,CGRP)的相关性。方法收集2018年5月至2021年5月本院128例GERD患者临床资料,根据GERD症状评分分级,将患者分为轻度、中度、重度及危重度四组。比较不同病情程度患者血清炎症因子(IL-6、IL-8及TNF-α)、SP及CGRP水平。分析GERD患者血清炎症因子与SP、CGRP的关系。采用ROC分析血清炎症因子、SP及CGRP判断GERD病情程度的价值。结果128例患者中轻度组30例,中度组42例,重度组34例,危重组22例。四组患者血清IL-6、IL-8、TNF-α、SP及CGRP水平比较,差异有统计学意义(P<0.05)。四组患者间两两比较,血清IL-6、IL-8、TNF-α、SP及CGRP水平差异有统计学意义(P<0.05)。血清IL-6、IL-8及TNF-α与SP、CGRP呈显著正相关性(P<0.05)。经多因素Logistic回归分析证实,IL-6、IL-8、TNF-α、CGRP及SP水平是影响GERD患者病情程度的危险因素(均P<0.05)。经ROC分析,血清IL-6、IL-8、TNF-α、CGRP及SP对判断GERD病情程度具有较高应用价值。CGRP和SP与血清炎症因子判断GERD患者病情程度的AUC病情程度比较,差异均无统计学意义(P>0.05)。结论GERD患者病情程度与血清炎症因子、SP及CGRP相关,且血清炎症因子与SP、CGRP间存在相关性,二者发挥协同作用,参与GERD病理进程。
Objective To study the correlation of serum inflammatory factor level with substance P(SP)and calcitonin gene-related peptide(CGRP)in patients with gastroesophageal reflux disease(GERD).Methods The clinical dataes of 128 GERD patients in our hospital from May 2018 to May 2021 were collected.According to the GERD symptom score,the patients were divided into 4 groups:mild group,moderate group,severe group and critical group.The serum inflammatory factors(IL-6,IL-8 and TNF-α),the SP and CGRP levels in patients with different disease degrees were compared.The relationship of serum inflammatory factors with SP and CGRP in GERD patients were analyzed.The ROC curve was used to analyze the value of serum inflammatory factors.SP and CGRP in judging the disease degrees of GERD.Results There were 30 cases in the mild group,42 cases in the moderate group,34 cases in the severe group and 22 cases in the critical group.There were significant difference of the serum IL-6,IL-8,TNF-α,SP and CGRP in the 4 groups(P<0.05).There were significant differences in pairwise comparison among the four groups in the levels of the serum IL-6,IL-8,TNF-α,SP and CGRP(P<0.05).There were significant positive correlation of serum IL-6,IL-8 with TNF-αand SP,CGRP(P<0.05).Multivariate Logistic regression analysis confirmed that IL-6,IL-8,TNF-α,CGRP,SP levels were the risk factors for critical illness in GERD patients(P<0.05).The ROC analysis showed that the serum IL-6,IL-8,TNF-α,CGRP and SP had high application value in judging GERD critical.There were no significant difference between CGRP and SP and serum inflammatory factors in judging AUC of critical GERD(P>0.05).Conclusion The disease degrees of GERD patients is related to serum inflammatory factors,SP and CGRP,and there is a correlation between serum inflammatory factors and SP and CGRP.They play a synergistic role and participate in the pathological process of GERD.
作者
李兰花
王利丽
LI Lanhua;WANG Lili(Department of Gastroenterology,Nanjing Tongren Hospital Affiliated to Southeast University School of Medicine,Nanjing 211102,China)
出处
《胃肠病学和肝病学杂志》
CAS
2023年第12期1333-1338,共6页
Chinese Journal of Gastroenterology and Hepatology
关键词
胃食管反流病
炎症因子
P物质
降钙素原基因相关肽
Gastroesophageal reflux disease
Inflammatory factors
Substance P
Calcitonin gene related peptide
