摘要
目的比对去白细胞悬浮红细胞保存期末溶血率的现行标准,并探索献血人群对去白细胞悬浮红细胞保存期末溶血率的影响因素,以制订合理的内控指标。方法回顾性分析南宁中心血站2015—2022年共8年427份去白细胞悬浮红细胞的保存期末溶血率数据。比对现行《全血及成分血质量要求》(GB 18469-2012)中保存期末溶血率标准,分析其差异性,并根据献血人群,分析影响溶血率的因素。结果(1)427例中有418例(97.89%)溶血率≤0.4%,均<0.8%;(2)从献血者人群特征分析,溶血率男性组>女性组;(3)在年龄的分组中18~29岁组的溶血率均低于30~39岁组和40~60岁组,组间差异有统计学意义;(4)职业分类中,学生溶血率最低,组间差异有统计学意义。(5)民族与血型,无统计学意义。结论数据统计表明献血者性别、年龄、献血量、职业均可以影响溶血率。现行的标准在本地区血液质量控制的合格范围明显偏高,宜制定合理的质控策略,将溶血率的内控指标设定为<0.4%,有利于对本地区内部质量控制做出准确的评价和保障血液安全。
Objective To compare the current standards and explore the influencing factors for hemolysis rate of leukocyte-reduced red blood cells at the end of the preservation period,in order to formulate reasonable internal control indicators.Methods A retrospective analysis was performed on hemolysis rate of 427 samples of leukocyte-reduced red blood cells at the end of the preservation period in Nanning Blood Center from 2015 to 2022.Compared with the current standard for hemolysis rate at the end of the preservation period(GB 18469-2012 Quality Requirements for Whole Blood and Component Blood),the differences were analyzed,and the factors influncing the hemolysis rate were analyzed in terms of different blood donor groups.Results (1)Among the 427 samples,the hemolysis rate of 418(97.89%)did not exceed 0.4%,all lower than 0.8%;(2)the hemolysis rate of the male group was higher than that of the female group;(3)the hemolysis rate of the 18-29 years old group was lower than that of the 30-39 year old group and the 40-60 year old group,with statistically significant difference;(4)in terms of occupation,the hemolysis rate of students was the lowest,and the differences between groups were statistically significant;(5)no statistical significance was found in ethnicity and blood type.Conclusion Statistics indicated that gender,age,blood donation volume and occupation of blood donors were the influencing factors of hemolysis rate.The current standard is obviously higher in the qualified range of blood quality control in Nanning.It is advisable to formulate a reasonable quality control strategy with internal control index of hemolysis rate set<0.4%,which is conducive to making accurate evaluation of internal quality control and ensuring blood safety.
作者
张刘娟
王心维
庞栋
潘阳春
韦振兴
李雄
朱秋亭
何汝汝
张翙
ZHANG Liujuan;WANG Xinwei;PANG Dong;PAN Yangchun;WEI Zhenxing;LI Xiong;ZHU Qiuting;HE Ruru;ZHANG Hui(Nanning Blood Center,Nanning 530000,China.)
出处
《中国输血杂志》
CAS
2023年第12期1147-1151,共5页
Chinese Journal of Blood Transfusion
关键词
溶血率
去白细胞悬浮红细胞
质量标准
献血人群
影响因素
内控指标
hemolysis rate
leukocyte-reduced red blood cells
quality standard
blood donors
influencing factors
internal control indicators
