摘要
为促进碳纳米管在修复神经损伤中的应用,以碳纳米管掺杂的纺织高聚物材料制备导电性人工神经导管的相关研究为基础,分析了碳纳米管的纳米形貌和导电性能在促进神经再生中的作用,概述了碳纳米管表面改性的作用与方法,综述了碳纳米管的生物医学应用、复合碳纳米管高聚物制备导电性人工神经导管的方法以及其神经再生效果。最后指出:碳纳米管用于制备导电性人工神经导管时应使其与生物体组织作用的界面保持纳米形貌;碳纳米管进行功能化改性后更有利于受损神经的再生与修复;应关注复合碳纳米管制备的神经导管在降解过程中可能带来的体内代谢毒性;碳纳米管掺杂高聚物在导电性神经导管的制备中具有突出的优势与广阔的应用前景。
Significance Currently,peripheral nerve injury causes great distress to patients,and artificial nerve conduits are used to replace autologous nerve grafting as an ideal treatment option.In the process of peripheral nerve injury and repair,the synergistic effect of conductive nerve conduits and electrical stimulation can greatly accelerate the regeneration and recovery of injured nerves,but polymers suitable for conduit formation are largely nonconductive.Thus,many studies prepare conductive artificial nerve conduits by adding conductive materials,such as carbon nanotubes(CNT),polypyrrole(PPy),and polyaniline(PANI),to the natural or synthetic polymers.Among the conductive materials,CNT has attracted much attention because of their better biocompatibility and excellent electrical conductivity.This review focuses on the physiochemical properties of CNT,their mechanisms for nerve repair and regeneration,the chemical modification of CNT and the formation methods of conductive nerve conduits,to better understand the nerve regeneration mechanism of CNT and clarifies the key progress and difficulties in preparing CNT-composited nerve conduits,hoping provide a beneficial reference for the preparation and application of carbon nanotubes in conductive nerve conduits.Progress The use of CNT for conductive nerve conduits has been mainly achieved by the doping of CNT with various types of natural or synthetic polymers.Current research mainly focuses on four aspects.The first is the exploration of the role and mechanism of the physiochemical properties of CNT in nerve regeneration.The morphological structure of CNT resembles that of neurites,and the microenvironment constructed by its nanotopography provides structural guidance for the adhesion and extension of neurons.Its anisotropic conductivity is also like that of neurons,and electrical coupling between CNT and neurons facilitates neural signal transmission.The second is the study of various modification methods of CNT to improve its biocompatibility and processability.The
作者
宋功吉
王煜煜
王善龙
王建南
许建梅
SONG Gongji;WANG Yuyu;WANG Shanlong;WANG Jiannan;XU Jianmei(College of Textile and Clothing Engineering,Soochow University,Suzhou,Jiangsu 215021,China;Key Laboratory of Textile Industry for Silk Products in Medical and Health Use,Soochow University,Suzhou,Jiangsu 215127,China)
出处
《纺织学报》
EI
CAS
CSCD
北大核心
2023年第11期232-239,共8页
Journal of Textile Research
基金
纺织行业医疗健康用蚕丝制品重点实验室项目(Q811580321)。
关键词
高聚物
碳纳米管
导电性
人工神经导管
纳米形貌
high polymer
carbon nanotube
conductivity
artificial nerve conduit
nanomorphology
