摘要
目的 分析双参数MRI(bpMRI)联合血清PSA水平与前列腺癌患者腹腔镜根治术预后的关系。方法 分析2019年6月至2021年9月新疆医科大学附属中医医院收治的84例前列腺癌患者的临床资料,根据患者的预后情况,将患者分为预后良好组(n=68)和预后不良组(n=16)。比较两组患者的临床资料、术前的bpMRI参数(ADC、Ktrans、Kep)及血清PSA水平,采用受试者工作特征(ROC)曲线分析术前的bpMRI参数及血清PSA水平预测前列腺癌根治术预后的价值。结果 预后良好组患者ADC值及血清PSA水平明显高于预后不良组,Ktrans、Kep值显著低于预后不良组,差异具有统计学意义(t=4.054、2.780;t=8.117、8.038;P<0.05)。经ROC曲线分析结果显示,术前bpMRI参数(ADC、Ktrans、Kep)及血清PSA水平预测前列腺癌患者腹腔镜根治术预后的曲线下面积分别为0.829(95%CI:0.743~0.914)、0.931(95%CI:0.813~0.980)、0.896(95%CI:0.785~0.983),0.689(95%CI:0.551~0.828);联合预测曲线下面积为0.969(95%CI:0.918~1.000),灵敏度达0.938,特异度达0.971,高于单一检测(P<0.05)。结论 双参数MRI联合血清PSA水平预测前列腺癌患者腹腔镜根治术预后具有较高的价值,可为临床前列腺癌患者腹腔镜根治术的预后评估提供参考。
Objective To analyze the relationship between two-parameter MRI(bpMRI)combined with serum PSA level and the prognosis of patients undergoing laparoscopic radical prostatectomy.Methods The clinical data of 84 patients with prostate cancer admitted to the Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University from June 2019 to September 2021 were retrospectively analyzed.According to the analysis of the ROC curve,the areas under the curve of preoperative bpMRI parameters(ADC,Ktrans,Kep)and serum PSA level for predicting the prognosis of patients with prostate cancer after laparoscopic radical surgery are 0.829(95%CI=0.743~0.914),0.931(95%CI=0.813~0.980)and 0.896(0.896),respectively.The area under the joint prediction curve is 0.969(95%CI=0.918~1.000),the sensitivity is 0.938 and the specificity is 0.971.Results The ADC value and serum PSA level in patients with good prognosis were significantly higher than those in patients with poor prognosis,while the values of Ktrans and Kep were significantly lower than those in patients with poor prognosis,with statistical significance(t=4.054,2.780;t=8.117,8.038;P<0.05).The ROC curve analysis showed that the areas under the curve for predicting the prognosis of patients with prostate cancer by preoperative bpMRI parameters(ADC,Ktrans,Kep)and serum PSA level were 0.829,0.931,0.896 and 0.689,respectively,and the area under the joint prediction curve was 0.969,with a sensitivity of 0.938 and a specificity of 0.971,which is higher than that of a single detection(P<0.05).Conclusion Two-parameter MRI combined with serum PSA level has high value in predicting the prognosis of laparoscopic radical prostatectomy,which can provide reference for the prognosis evaluation of laparoscopic radical prostatectomy.
作者
张梅
马娟
马海婷
左晨
ZHANG Mei;MA Juan;MA Haiting;ZUO Chen(Department of Medical Imaging,Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University,Urumqi,Xinjiang,China,830000)
出处
《分子诊断与治疗杂志》
2023年第11期2020-2023,共4页
Journal of Molecular Diagnostics and Therapy
基金
新疆医科大学附属中医医院院级课题(ZYY202108)。
关键词
双参数MRI
前列腺特异性抗原
前列腺癌
腹腔镜根治术
Biparametric MRI
Prostate specific antigen
Prostate cancer
Laparoscopic radical operation
