摘要
目的研究前列腺特异性膜抗原(PSMA)在前列腺癌中的表达及其与Gleason分级之间的关系,同时探讨其在前列腺癌诊断中的价值。方法采用免疫组化EnVision法检测PSMA在前列腺癌、前列腺上皮内瘤变(PIN)和良性前列腺增生症(BPH)中的表达。结果PSMA在BPH、PIN和前列腺癌中均表达。在BPH中,PSMA阳性表达部位在前列腺腔缘或顶端/胞质表达,而在PIN中表达模式为胞质伴胞膜阳性,前列腺癌为顶端/胞质、胞质伴胞膜阳性或胞质表达阳性。PSMA在分化差前列腺癌中多为胞质表达,而在分化好的癌中为顶端/胞质和胞质伴胞膜表达。PSMA表达强度在PIN和前列腺癌中明显高于BPH(P<0.05),同时PSMA染色强度与Gleason评分呈正相关(P<0.05)。结论PSMA与Gleason分级密切相关,PSMA表达模式和染色强度的改变对PIN和前列腺癌诊断具有参考价值。
Purpose To study the expression of prostate-specific membrane antigen （PSMA） in prostate adenocarcinoma and relationship with Gleason grade, and to explore the value of PSMA in diagnosis of prostate adenocarcinoma. Methods Expression of PSMA in benign prostate hyperplasia （BPH） , prostate intraepithelial neoplasia （PIN） and prostate carcinoma were detected with EnVision immunohistochemical staining. Results Expression of PSMA was observed in all cases of BPH, PIN and prostate carcinoma. PSMA expression pattern showed apical （luminal） or apical/cytoplasmic in BPH, apical/cytoplasmic in PIN, cytoplasmic with membranous accentuation or cytoplasmic staining in prostate carcinoma. The cytoplasmic staining of PSMA was observed in the majority of prostate poorly-differentiated carcinoma, apical/cytoplasmic or cytoplasmic with membranous accentuation in well-differentiated carcinoma. PSMA staining intensity in PIN and prostate carcinoma was higher than that in BPH（ P 〈 0. 05 ）. The staining intensity of PSMA was positively correlated with Gleason grade （ P 〈 0. 05 ）. Conclusions Expression of PSMA is correlated with Gleason grade. PSMA expression pattern and intensity may be a useful surrogate marker in diagnosing PIN and prostate carcinoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2008年第2期215-218,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
前列腺肿瘤
前列腺特异性膜抗原
良性前列腺增生症
前列腺上皮内肿瘤
prostate neoplasm
prostate-specific membranous antigen
benign prostate hyperplasia
prostate intraepithelial neoplasia
