摘要
目的检测前列腺特异性膜抗原、α-甲基酰基辅酶A消旋酶在前列腺癌的表达情况,探讨其在前列腺癌中的意义.方法采用免疫组化En Vision法观察前列腺特异性膜抗原、α-甲基酰基辅酶A消旋酶的表达特点.结果 (1)前列腺特异性膜抗原在前列腺癌中的表达分别强于良性前列腺增生(P=0.000)和高级别前列腺上皮内瘤变中的表达(P=0.005),前列腺特异性膜抗原的表达与Gleason评分及预后(P>0.05)均不相关.(2)α-甲基酰基辅酶A消旋酶在良性前列腺增生中的表达明显低于高级别前列腺上皮内瘤变(P=0.000)和前列腺癌(P=0.000)中的表达,且与Gleason评分呈负相关(P=0.005,rs=-0.430);与预后不相关(P>0.05).结论前列腺特异性膜抗原、α-甲基酰基辅酶A消旋酶在前列腺癌的发生发展中起一定作用,但不能作为预测预后的指标.
Objective To detect the expression of prostate-specific Membrane Antigen （PSMA）,and α-methylacyl CoA Racemase （AMACR） in prostate carcinoma and explore its significance in the development of prostate carcinoma.Method The expression of PSMA,and AMACR was detected by immunohistochemistry.Results （1） The expression levels of PSMA were higher in prostate carcinoma （Pca） than those in benign prostatic hyperplasia （BPH） （P=0.000） and high grade prostatic intraepithelial neoplasia （HGPIN） （P=0.005）,there was no correlation between Gleason score,prognosisand the expression of PSMA （P ＞0.05）.2.The expression levels of AMACR in BPH were obviously lower than those of in HGPIN （P=0.000） and Pca （P=0.000）,the expression of AMACR was negatively correlated with Gleason score （P=0.005,rs =-0.430） ; and was not correlated with prognosis （P＞0.05）.Cornclusion PSMA and AMACR play a role in the development of prostate carcinoma,but could not be as predictors of prognosis.
出处
《昆明医科大学学报》
CAS
2014年第12期49-53,共5页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81260361)
云南省应用基础研究基金资助项目(2010CD079)
