摘要
目的探讨采用不同腹腔镜下前列腺癌根治术治疗前列腺癌患者的效果,以及对睾酮水平、前列腺特异性抗原(PSA)水平的作用。方法选取2018年1月至2023年12月九江学院附属医院泌尿外科收治的60例前列腺癌患者作为研究对象,采用随机数字表法分为对照组和观察组,每组各30例,对照组采用常规腹腔镜前列腺癌根治术+盆腔淋巴结清扫术,观察组采用改良式腹腔镜下前列腺癌根治术联合盆腔淋巴结清扫术。比较两组治疗效果、总睾酮水平、PSA水平、性功能及并发症情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗前总睾酮水平及PSA水平比较,差异无统计学意义(P>0.05),治疗后观察组总睾酮水平高于对照组,差异有统计学意义(P<0.05),观察组游离前列腺特异抗原(F-PSA)、总前列腺特异抗原(T-PSA)水平低于对照组,差异有统计学意义(P<0.05)。治疗前两组性功能比较,差异无统计学意义(P>0.05),治疗后观察组勃起功能国际问卷-5(IIEF-5)评分高于对照组,早泄诊断量表(PEDT)评分低于对照组,差异有统计学意义(P<0.05)。观察组并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论腹腔镜前列腺癌根治术在前列腺癌治疗中能有效改善性功能,还能提高患者体内的总睾酮水平、降低PSA水平,减少并发症的发生,是一种值得临床推广的前列腺癌治疗方法。
Objective To investigate the effect of different laparoscopic radical resection of prostate cancer on the level of testosterone and prostate specific antigen(PSA).Methods A total of 60 patients with prostate cancer admitted to the Department of Urology of the Jiujiang University Affiliated Hospital from January 2018 to December 2023 were selected as the research objects,and they were divided into the control group and the observation group by random number table method,with 30 cases in each group.The control group received conventional laparoscopic radical resection of prostate cancer and pelvic lymph node dissection,and the observation group received improved laparoscopic radical resection of prostate cancer combined with pelvic lymph node dissection.The therapeutic effect,total testosterone level,PSA level,sexual function and complications were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There were no statistical significances in the total testosterone level and PSA level between the two groups before treatment(P>0.05).After treatment,the total testosterone level in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The levels of free prostate specific antigen(F-PSA)and total prostate specific antigen(T-PSA)in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in sexual function between the two groups(P>0.05).After treatment,the international questionnaire 5(IIEF-5)score of the observation group was higher than that of the control group,and the premature ejaculation diagnostic scale(PEDT)score was lower than that of the control group,with statistical significances(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,the dif
作者
张良
陆文宝
廖鑫鑫
张谏
黄玉清
ZHANG Liang;LU Wenbao;LIAO Xinxin;ZHANG Jian;HUANG Yuqing(Department of Urology,Jiujiang University Affiliated Hospital,Jiangxi Province,Jiujiang 332200,China)
出处
《中国当代医药》
CAS
2024年第28期56-60,共5页
China Modern Medicine
基金
江西省卫生健康委普通科技计划项目(20197194)。
关键词
腹腔镜前列腺癌根治术
前列腺癌
睾酮水平
前列腺特异性抗原
Laparoscopic radical prostatectomy for prostate cancer
Prostate cancer
Testosterone levels
Prostate specific antigen
