摘要
目的 探讨盐酸氨溴索静脉注射联合布地奈德雾化吸入对新生儿肺炎及超敏C反应蛋白(hs-CRP)、降钙素原(PCT)的影响。方法 选取2020年4月至2022年8月肇庆市端州区妇幼保健院收治的200例肺炎患儿作为研究对象,随机分为观察组与对照组,各100例。对照组采用盐酸氨溴索治疗,观察组在对照组基础上联合布地奈德雾化吸入治疗。比较两组临床疗效、症状消失时间及住院时间、血清炎症因子、血气指标。结果观察组治疗有效率为95.00%,高于对照组的87.00%,差异有统计学意义(χ^(2)=3.907,P=0.048);观察组发热、咳嗽、气喘、湿啰音、呼吸困难消失时间以及住院时间短于对照组,差异有统计学意义(P<0.05);干预前,两组hs-CRP、PCT水平比较差异无统计学意义(P>0.05),干预后,两组hs-CRP、PCT水平降低,且观察组低于对照组,差异有统计学意义(P<0.05);干预前,两组动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))水平比较差异无统计学意义(P>0.05),干预后两组PaO_(2)、SaO_(2)水平升高,且观察组高于对照组,PaCO_(2)水平降低,且观察组低于对照组,差异有统计学意义(P<0.05)。结论 对新生儿肺炎患儿采用盐酸氨溴索静脉注射联合布地奈德雾化吸入能有效提高临床疗效,并促使症状早日消失,有利于肺功能改善。
Objective To explore the effects of intravenous injection of ambroxol hydrochloride combined with budesonide aerosol inhalation on neonatal pneumonia,hypersensitive C-reactive protein(hs-CRP)and procalcitonin(PCT).Methods A total of 200 children with pneumonia treated in Duanzhou Maternal and Child Health Hospital of Zhaoqing City from April 2020 to August 2022 were selected as the study objects and randomly divided into observation group and control group,with 100 cases in each group.The control group was treated with ambroxol hydrochloride,and the observation group was treated with budesonide aerosol inhalation on the basis of the control group.The clinical efficacy,duration of symptom disappearance and hospitalization,serum inflammatory factors and blood gas indexes were compared between the two groups.Results The effective rate in the observation group was 95.00%,higher than that in the control group(87.00%),the difference was statistically significant(χ^(2)=3.907,P-0.048).The disappearance time of fever,cough,asthma,moist rales,dyspnea and hospital stay in the observation group were shorter than those in the control group,the difference was statistically significant(P<0.05).Before intervention,there was no statistically significant difference in the levels of hs-CRP and PCT between the two groups(P>0.05).After intervention,the levels of hs-CRP and PCT between the two groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Before intervention,there was no significant difference in the levels of arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2))and arterial oxygen saturation(SaO_(2))between the two groups(P>0.05).After intervention,the levels of PaO_(2) and SaO_(2) increased between the two groups,and the observation group was higher than the control group,while the PaCO_(2) level decreased,and the observation group was lower than the control group,the difference was statistically sign
作者
李炳灿
朱丽兴
LI Bing-Chan;ZHU Li-Xing(Department of Neonatology,Duanzhou Maternal and Child Health Hospital,Zhaoqing City,Zhaoqing 526060,China)
出处
《中国药物经济学》
2023年第10期80-83,共4页
China Journal of Pharmaceutical Economics
关键词
盐酸氨溴索
布地奈德
新生儿肺炎
超敏C反应蛋白
降钙素原
Ambroxol hydrochloride
Budesonide
Neonatal pneumonia
Hypersensitive C-reactive protein
Procalcitonin
