摘要
目的 探讨血清超敏C反应蛋白(hs-CRP)、高密度脂蛋白胆固醇(HDL-C)、同型半胱氨酸(Hcy)与急性脑梗死(ACI)患者认知障碍及抑郁状态相关性研究。方法 回顾性分析河南大学第一附属医院2020年8月至2022年8月收治的80例ACI患者的临床资料,根据是否合并认知障碍分为认知障碍组(46例)、认知正常组(34例),并根据是否合并脑卒中后抑郁(PSD)分为PSD组(26例)、非PSD组(54例),比较各组血清hs-CRP、HDL-C、Hcy水平,采用Spearman相关分析血清hs-CRP、HDL-C、Hcy水平与ACI患者认知障碍、抑郁状态的相关性,并采用受试者工作特征曲线(ROC曲线)分析hs-CRP、HDL-C、Hcy对ACI患者认知障碍及抑郁状态的预测价值。结果 认知障碍组患者血清hs-CRP、Hcy水平高于认知正常组患者,而血清HDL-C水平低于认知正常组患者(P<0.05)。PSD组患者血清hs-CRP、Hcy水平高于非PSD组患者,而血清HDL-C水平低于非PSD组患者(P<0.05)。Spaerman相关分析显示,血清hs-CRP、Hcy水平与ACI患者认知障碍、抑郁状态呈明显正相关(P<0.01),而血清HDL-C水平与ACI患者认知障碍、抑郁状态呈明显负相关(P<0.01)。ROC曲线显示,hs-CRP、HDL-C、Hcy对AIS患者认知障碍、抑郁状态具有一定预测价值(AUC=0.900、0.790、0.890,0.887、0.748、0.843,P<0.01),且三项联合(AUC=0.990,0.985,P<0.01)预测价值较高。结论 血清hs-CRP、Hcy水平与ACI患者认知障碍、抑郁状态呈正相关,而血清HDL-C水平与ACI患者认知障碍、抑郁状态呈负相关,血清hs-CRP、HDL-C、Hcy联合检测对ACI患者认知障碍、抑郁状态具有较高预测价值。
Objective To investigate the correlation between serum hypersensitive C-reactive protein(hs-CRP),high density lipoprotein cholesterol(HDL-C),homocysteine(Hcy)and cognitive impairment and depression in pa⁃tients with acute cerebral infarction(ACI).Methods The clinical data of 80 ACI patients admitted from August 2020 to August 2022 were retrospectively analyzed,and they were divided into cognitive impairment group(46 cases)and normal cognitive group(34 cases)according to whether they were complicated with cognitive impairment,and PSD group(26 cases)and non-PSD group(54 cases)according to whether they were complicated with poststroke depres⁃sion(PSD).Serum hs-CRP,HDL-C and Hcy levels were compared among all groups,and Spearman correlation was used to analyze the correlation between serum hs-CRP,HDL-C and Hcy levels and cognitive impairment and depres⁃sion in ACI patients.Receiver operating characteristic curve(ROC curve)was used to analyze the predictive value of hs-CRP,HDL-C and Hcy for cognitive impairment and depression in ACI patients.Results The serum hs-CRP and Hcy levels in cognitive impairment group were higher than those in cognitive normal group,while the serum HDL-C levels were lower than those in cognitive normal group(P<0.05).The serum hs-CRP and Hcy levels in PSD group were higher than those in non-PSD group,while the serum HDL-C levels were lower than those in non-PSD group(P<0.05).Spaerman correlation analysis showed that serum hs-CRP and Hcy levels were significantly positively cor⁃related with cognitive impairment and depressive state in ACI patients(P<0.01),while serum HDL-C levels were significantly negatively correlated with cognitive impairment and depressive state in ACI patients(P<0.01).ROC curve showed that hs-CRP,HDL-C and Hcy had certain predictive value on cognitive impairment and depression in AIS patients(AUC=0.900,0.790,0.890,0.887,0.748,0.843,P<0.01),and the combination of the three factors(AUC=0.990,0.985,P<0.01)had high predictive value.Conclusion Serum hs-CRP and Hcy level
作者
李阳阳
刘欣欣
王晓雪
LI Yang-yang;LIU Xin-xin;WANG Xiao-xue(Department of Geriatric Neurology,the First Affiliated Hospital of Henan University,Kaifeng,Henan 475000,China)
出处
《医药论坛杂志》
2023年第20期25-29,共5页
Journal of Medical Forum
基金
河南省高等学校重点科研项目(18B310013)。
关键词
超敏C反应蛋白
高密度脂蛋白胆固醇
同型半胱氨酸
急性脑梗死
认知障碍
抑郁状态
Hypersensitive C-reactive protein
High density lipoprotein cholesterol
Homocysteine
Acute cerebral in⁃farction
Cognitive impairment
State of depression
