摘要
目的探讨老年急性脑梗死(acute cerebral infarct,ACI)患者血清β2微球蛋白(β2-MG)、同型半胱氨酸(homocysteine,Hcy)及脑利钠肽前体(pro-BNP)与认知功能的相关性。方法选取2017年9月-2020年3月海安市人民医院收治的老年ACI患者88例为研究组,同期年龄、性别相仿的健康体检者79例为参照组,检测两组血清β2-MG、Hcy和pro-BNP水平变化,采用NIHSS和MoCA量表评价神经功能及认知功能,分析血清β2-MG、Hcy和pro-BNP水平与老年ACI患者认知功能的相关性。结果研究组NIHSS评分高于参照组,MoCA评分低于参照组,研究组血清β2-MG、Hcy和pro-BNP水平均高于参照组(均P<0.01)。血清β2-MG、Hcy和pro-BNP水平随着脑梗死、神经损伤及认知功能障碍严重程度呈升高趋势(P<0.05)。血清β2-MG、Hcy和pro-BNP水平与MoCA评分负相关,与NIHSS评分正相关。结论血清β2-MG、Hcy和pro-BNP水平与ACI发生及患者认知功能障碍密切相关。
Objective To investigate the correlation of serumβ2-microglobulin(β2-MG),homocysteine(Hcy),and pro-brain natriuretic peptide(pro-BNP)with cognitive dysfunction in elderly patients with acute cerebral infarction(ACI).Methods Fasting peripheral blood samples were collected from 88 ACI patients,aged(72.19±5.37)(60~79)(study group)and 79 age and gender-matched people undergoing health examination(control group).ELISA was used to test the levels of serumβ2-MG,Hcy and pro-BNP in the two groups were detected.At the same time,NIHSS and MoCA were used to evaluate the neurological and cognitive functions.The correlation between cognitive function and serumβ2-MG,Hcy and pro-BNP was analyzed.Results The NIHSS score of study group was(24.78±7.19),signifi‐cantly higher than that of the control group[(3.80±1.22),P<0.05].The MOCA score of the study group was(13.47±2.81),significantly lower than that of the control group[(28.25±2.06),P<0.05].The levels of serumβ2-MG,Hcy,and pro-BNP pf the study group were(4.53±0.66)mg/L,(14.37±4.16)μmol/L,and(82.31±12.54)pg/mL respectively,all significantly higher than those of the control group[(3.88±0.71)mg/L,(10.12±2.88)μmol/L,and(82.31±12.54)pg/mL respectively,all P<0.05].The levels of serumβ2-mg,Hcy and pro BNP increased with the severity of cerebral infarc‐tion,nerve injury and cognitive impairment(P<0.05).The levels of serumβ2-MG,Hcy and pro-BNP were negatively correlated with the MoCA score,and positively correlated with NIHSS score.Conclusion The serum levels ofβ2-MG,Hcy and pro BNP are closely related to the occurrence of ACI and cognitive dysfunction.
作者
温慧灵
陆建力
吴兆华
WEN Huiling;LU Jianli;WU Zhaohua(Department of Emergency Medicine,Hai'an People's Hospital,Hai'an Jiangsu 226600,China)
出处
《中国急救复苏与灾害医学杂志》
2021年第9期1004-1007,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
江苏省卫生健康委科研立项(编号:Z2019034)。
关键词
急性脑梗死
认知功能
Β2-微球蛋白
同型半胱氨酸
脑利钠肽前体
Acute cerebral infarction(ACI)
Cognitive impairment
β2-Microglobulin
Homocysteine
Pro-brain natri‐uretic peptide(pro-BNP)
