摘要
目的:分析"H型"高血压患者血脂四项及血清同型半胱氨酸(Hcy)水平与急性脑梗死发生的相关性.方法:将我院2018年8月至2019年7月收治的80例"H型"高血压患者作为研究对象,根据其是否发生急性脑梗死将患者分为急性脑梗死组(n=30)和非急性脑梗死组(n=50),另选择同期于我院进行体检的40例健康人群作为对照组,对比三组一般资料和血脂四项[甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)及高密度脂蛋白(HDL-C)]和血清Hcy水平,分析"H型"高血压患者血脂四项及血清Hcy水平与急性脑梗死发生的相关性.结果:急性脑梗死组和非急性脑梗死组收缩压均高于对照组(P<0.05);急性脑梗死组血清TC、TG、LDL-C、Hcy水平均高于非急性脑梗死组(P<0.05),血清HDL-C水平低于非急性脑梗死组(P<0.05);血清TC、TG、LDL-C、Hcy水平与急性脑梗死发呈正相关(P<0.05),血清HDL-C水平与急性脑梗死发生呈负相关(P<0.05);血清TC、TG、HDL-C、LDL-C、Hcy是"H型"高血压患者发生急性脑梗死的影响因素(P<0.05).结论:"H型"高血压患者血脂四项及血清Hcy水平与急性脑梗死发生存在相关性,临床监测血脂四项、血清Hcy水平,对评估"H型"高血压患者急性脑梗死发生具有重要价值.
Objective:To analyze the correlation between levels of four serum lipid indexes,serum homocysteine(Hcy)and occurrence of acute cerebral infarction(ACI)in patients with H-type hypertension.Methods:Eighty patients with H-type hypertension who were admitted to the hospital from August 2018 to July 2019 were enrolled as study objects.According to presence or absence of ACI,they were divided into ACI group(n=30)and non-ACI group(n=50).Another 40 healthy people after physical examination in the hospital during the same period were enrolled as control group.The general data,levels of four serum lipid indexes[triglyceride(TG),cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]and serum Hcy were compared among the three groups.The correlation between levels of four serum lipid indexes,serum Hcy and occurrence of ACI in patients with H-type hypertension was analyzed.Results:The systolic blood pressure in ACI group and non-ACI group was higher than that in control group(P<0.05).Serum TC,TG,LDL-C and Hcy levels in ACI group were higher than those in non-ACI group(P<0.05),while serum HDL-C levels were lower than non-ACI group(P<0.05).Serum TC,TG,LDL-C and Hcy levels were positively correlated with the occurrence of ACI(P<0.05),while serum HDL-C level was negatively correlated with it(P<0.05).Serum TC,TG,HDL-C,LDL-C and Hcy were influencing factors of ACI in patients with H-type hypertension(P<0.05).Conclusion:There is correlation between levels of four serum lipid indexes,serum Hcy and occurrence of ACI in patients with H-type hypertension.Clinical monitoring on levels of four serum lipid indexes and serum Hcy is of important value for assessing occurrence of ACI in patients with H-type hypertension.
作者
王俊珺
王本孝
唐永亮
施燕红
王鹏
WANG Junjun;WANG benxiao;TANG Yongliang(Wanbei Coal Power Group General Hospital/the Third Affiliated Hospital of Bengbu Medical College,Anhui Suzhou 234011,China)
出处
《河北医学》
CAS
2020年第7期1130-1133,共4页
Hebei Medicine
基金
安徽省卫生厅资助基金项目,(编号:2015010315)。
关键词
"H型"高血压
血脂四项
同型半胱氨酸
急性脑梗死
H-type hypertension
Four serum lipid indexes
Homocysteine
Acute cerebral infarction
