摘要
[目的]探讨熄风通瘀开窍方联合电针治疗急性脑梗死临床疗效及机制。[方法]将164例急性脑梗死患者采用随机数字表分为4组,对照组(41例,常规西医治疗)、电针组(41例,常规西医+电针治疗)、汤剂组(41例,常规西医+熄风通瘀开窍方治疗)、联合组(41例,常规西医+熄风通瘀开窍方+电针治疗)。对比4组治疗前、1周后、2周后炎症[肿瘤坏死因子-α(TNF-α)超敏C反应蛋白(hs-CRP)、白介素-1β(IL-1β)]、氧化应激[丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)、谷胱甘肽过氧化物酶(GSH-Px)]、神经功能[美国国立卫生院神经功能缺损量表(NIHSS)]变化,病情转归情况。[结果]血清炎症因子、氧化应激指标及NIHSS评分经重复测量方差分析差异均有统计学意义(P<0.05);4组1、2周后血清炎症因子、MDA水平、NIHSS评分均低于治疗前(P<0.05),2周后均低于1周后(P<0.05),且1周后、2周后联合组均低于其余3组(P<0.05),电针组、汤剂组均低于对照组(P<0.05);4组1周后、2周后血清SOD、NO和GSH-Px均高于治疗前(P<0.05),2周后均高于1周后(P<0.05),且1、2周后联合组均高于其余3组(P<0.05),电针组、汤剂组均高于对照组(P<0.05);联合组预后良好率高于其余3组(P<0.01)。[结论]熄风通瘀开窍方和电针均可减轻急性脑梗死患者的炎症、氧化应激及神经功能缺损程度,两者联合效果更佳且可有效促进病情转归。
[Objective]To explore the effect of Xifeng Tongyu Kaiqiao Recipe combined with electro-acupuncture on the patients with acute cerebral infarction.[Methods]The 164 patients with acute cerebral infarction were randomly divided into control group(41 cases,routine Western medicine treatment),electro-acupuncture group(41 cases,routine Western medicine+electroacupuncture treatment),decoction group(41 cases,routine Western medicine+Xifeng Tongyu Kaiqiao Recipe),combined group(41 cases,routine Western medicine+Xifeng Tongyu Kaiqiao Recipe+electro-acupuncture).The changes of inflammation[tumor necrosis factor-α(TNF-α),high sensitivity C-reactive protein(hs-CRP),interleukin-1β(IL-1β)],oxidative stress[malondialdehyde(MDA),superoxide dismutase(SOD),nitric oxide(NO),glutathione peroxidase(GSH-Px)]and neurological function(NIHSS)before treatment,1 week and 2 weeks after treatment,prognosis of the disease were compared among the 4 groups.[Results]There were statistically significant differences in the serum inflammatory factors,oxidative stress indexes and NIHSS scores by variance by repeated measurement analysis(P<0.05).After 1 week and 2 weeks,serum inflammatory factors,MDA levels and NIHSS scores of the four groups were lower than those before treatment(P<0.05),and those after 2 weeks were lower than those after 1 week(P<0.05),which in the combination group were lower than those in the other three groups after 1 week and 2 weeks(P<0.05),and those in the electro-acupuncture group and decoction group were lower than those in the control group(P<0.05).The serum SOD,NO and GSH PX in the four groups after 1 week and 2 weeks were higher than those before treatment(P<0.05),and those after 2 weeks were higher than those after 1 week(P<0.05),and those in the combination group after 1 week and 2 weeks were higher than those in the other three groups(P<0.05),and those in the electro-acupuncture group and decoction group were higher than those in the control group(P<0.05).The good prognosis rates of the combined group,electro-acupu
作者
赵少宁
王连军
张占鹏
刘德泉
常晶晶
卢月英
ZHAO Shaoning;WANG Lianjun;ZHANG Zhanpeng;LIU Dequan;CHANG Jingjing;LU Yueying(Department of Encephalopathy Rehabilitation,Langfang Hospital of Traditional Chinese Medicine,Langfang 065000,China)
出处
《天津中医药》
CAS
2022年第2期193-198,共6页
Tianjin Journal of Traditional Chinese Medicine
基金
廊坊市科技支撑计划项目(2018013066)。
关键词
熄风通瘀开窍方
电针
急性脑梗死
炎症
氧化应激
神经功能
Xifeng Tongyu Kaiqiao Recipe
electro-acupuncture
acute cerebral infarction
inflammation
oxidative stress
nerve function
